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      The stability of blood Eosinophils in chronic obstructive pulmonary disease

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          Abstract

          Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.

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          Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials.

          Peter M A Calverley, Stephen Rennard, Kai T. Richter … (2018)
          The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD.
          Article 0 comments Cited 165 times – based on 0 reviews     Review now
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            Blood and sputum eosinophils in COPD; relationship with bacterial load

            Umme Kolsum, Gavin C. Donaldson, Richa Singh … (2017)
            Background Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophil counts are inversely related. Methods COPD patients were seen at stable state and exacerbation onset. Sputum was processed for quantitative polymerase chain reaction detection of the potentially pathogenic microorganisms (PPM) H. influenzae, M. catarrhalis and S. pneumoniae. PPM positive was defined as total load ≥1 × 104copies/ml. Sputum and whole blood were analysed for differential cell counts. Results At baseline, bacterial counts were not related to blood eosinophils, but sputum eosinophil % was significantly lower in patients with PPM positive compared to PPM negative samples (medians: 0.5% vs. 1.25% respectively, p = 0.01). Patients with PPM positive samples during an exacerbation had significantly lower blood eosinophil counts at exacerbation compared to baseline (medians: 0.17 × 109/L vs. 0.23 × 109/L respectively, p = 0.008), while no blood eosinophil change was observed with PPM negative samples. Conclusions These findings indicate an inverse relationship between bacterial infection and eosinophil counts. Bacterial infection may influence corticosteroid responsiveness by altering the profile of neutrophilic and eosinophilic inflammation. Electronic supplementary material The online version of this article (doi:10.1186/s12931-017-0570-5) contains supplementary material, which is available to authorized users.
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              Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts.

              Olorunfemi Oshagbemi, Andrea M. Burden, Dionne C W Braeken … (2017)
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                Author and article information

                Contributors
                Gabriella H. Long:
                ORCID: http://orcid.org/0000-0001-9286-2887
                gabriella.long@postgrad.manchester.ac.uk
                Journal
                Journal ID (nlm-ta): Respir Res
                Journal ID (iso-abbrev): Respir. Res
                Title: Respiratory Research
                Publisher: BioMed Central (London )
                ISSN (Print): 1465-9921
                ISSN (Electronic): 1465-993X
                Publication date (Electronic): 10 January 2020
                Publication date PMC-release: 10 January 2020
                Publication date (Print): 2020
                Volume: 21
                Electronic Location Identifier: 15
                Affiliations
                [1 ]ISNI 0000000121662407, GRID grid.5379.8, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, , The University of Manchester, ; Manchester, UK
                [2 ]GRID grid.498924.a, Medicines Evaluation Unit, , Manchester University NHS Foundation Trust, ; Manchester, UK
                [3 ]ISNI 0000 0001 2113 8111, GRID grid.7445.2, National Heart and Lung Institute, Imperial College London, ; London, UK
                [4 ]ISNI 0000 0004 1936 8411, GRID grid.9918.9, Institute for Lung Health, University of Leicester, ; Leicester, UK
                Author information
                http://orcid.org/0000-0001-9286-2887
                Article
                Publisher ID: 1279
                DOI: 10.1186/s12931-020-1279-4
                PMC ID: 6954589
                PubMed ID: 31924207
                SO-VID: acb3b8c0-86dd-42da-a19e-7d900ee3189a
                Copyright © © The Author(s). 2020
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 26 August 2019
                Date accepted : 5 January 2020
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100014653, Manchester Biomedical Research Centre;
                Categories
                Subject: Letter to the Editor
                Custom metadata
                issue-copyright-statement © The Author(s) 2020

                ScienceOpen disciplines: Respiratory medicine
                Keywords: copd,eosinophil,airway inflammation
                Data availability:
                ScienceOpen disciplines: Respiratory medicine
                Keywords: copd, eosinophil, airway inflammation

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