Impact of IL1R1 and IL1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case–control study

Abstract

Aim

Osteonecrosis of the femoral head ( ONFH) refers to bony changes caused by osteocyte death under the effects of complicated factors, which is caused by genetic factors and certain risk factors. Our study aimed to explore whether IL1R1/ IL1R2 polymorphisms influenced ONFH risk in the Chinese Han population.

Methods

We selected 286 patients and 441 controls, with 11 single‐nucleotide polymorphisms in IL1R1 and IL1R2 gene were successfully genotyped, and evaluated the associations using the chi‐squared test, Fisher's exact test, T test, and genetic model analyses. Odds ratios and 95% confidence intervals ( CIs) were calculated using unconditional logistic regression.

Results

In the allele model, rs11674595 in IL1R2 was associated with increasing the risk of ONFH, the rs10490571 and rs3917225 in IL1R1 gene were associated with an increased risk of ONFH, respectively. In the genetic model, the rs11674595 in IL1R2 gene was associated with an increased risk of ONFH in the codominant model, dominant model, and log‐additive model, respectively. The rs10490571 and rs3917225 in IL1R1 gene conferred an increased risk of ONFH in the codominant model, dominant model, and log‐additive model, respectively. We found none of the haplotypes in the IL1R2 gene was significantly associated with the ONFH risk.

Conclusion

Our findings have demonstrated that the rs11674595 ( IL1R2 ), rs10490571, and rs3917225 ( IL1R1 ) were significantly associated with increasing the ONFH risk in the Chinese Han population.