Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial.

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Abstract

Intravascular-catheter-related infections are frequent life-threatening events in health care, but incidence can be decreased by improvements in the quality of care. Optimisation of skin antisepsis is essential to prevent short-term catheter-related infections. We hypothesised that chlorhexidine-alcohol would be more effective than povidone iodine-alcohol as a skin antiseptic to prevent intravascular-catheter-related infections.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Nov 21 2015

Volume: 386

Issue: 10008

Affiliations

[1 ] Service d'Anesthésie et de Réanimation, CHU de Poitiers, Poitiers, France; Université de Poitiers, UFR de Médecine Pharmacie, Poitiers, France; INSERM U1070, Pharmacologie des Agents antiInfectieux, Poitiers, France. Electronic address: olivier.mimoz@chu-poitiers.fr.

[2 ] AP-HP, Bichat University Hospital, Infection Control Unit, Paris, France; INSERM, UMR 1137-IAME Team 5-DeSCID: Decision Sciences in Infectious Diseases, Control and Care, Paris, France; Univ Paris Diderot, Sorbonne Paris Cité, Paris, France.

[3 ] Service d'Anesthésie et de Réanimation, CHU de Poitiers, Poitiers, France.

[4 ] Service de Réanimation Adultes et Unité de Surveillance Continue, CHU Clermont Ferrand, Clermont Ferrand, France.

[5 ] Service de Réanimation médicale, CHU Clermont Ferrand, Clermont-Ferrand, France.

[6 ] Service de Réanimation Médicale, CHU de Poitiers, Poitiers, France.

[7 ] Département de Réanimation Médicale et Médecine Hyperbare, CHU d'Angers, Angers, France.

[8 ] INSERM, UMR 1137-IAME Team 5-DeSCID: Decision Sciences in Infectious Diseases, Control and Care, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France.

[9 ] Service de Réanimation Chirurgicale, CHU d'Angers, Angers, France.

[10 ] Service de Réanimation et Maladies infectieuses, CH de Tourcoing, Tourcoing, France.

[11 ] Service d'Anesthésie et de Réanimation Médicale et Chirurgicale, CHU Lyon-Sud, Lyon, France.

[12 ] Service de Réanimation Chirurgicale, Hôpital Bichat-Claude-Bernard, Paris, France.

[13 ] OutcomeRéa, Paris, France.

Article

Publisher Item ID: S0140-6736(15)00244-5

DOI: 10.1016/S0140-6736(15)00244-5

PubMed ID: 26388532

SO-VID: acb62b9a-0b28-4350-9920-1923010a9438

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