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      Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7

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          Abstract

          Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various pharmacological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities. The present study aimed to evaluate the antioxidant activity and expression of antioxidant enzymes of C. sappan L. extract and its major compound, brazilin, in human epidermal keratinocytes exposed to UVA irradiation. Our results indicated that C. sappan L. extract reduced UVA-induced H 2O 2 production via GPX7 activation. Moreover, brazilin exhibited antioxidant effects that were similar to those of C. sappan L. via glutathione peroxidase 7 (GPX7), suggesting that C. sappan L. extract and its natural compound represent potential treatments for oxidative stress-induced photoaging of skin.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 March 2017
          : 16
          : 3
          : 203-209
          Affiliations
          1Department of Oriental Cosmetic Science, Semyung University, Chungbuk 390-711, Republic of Korea
          Author notes
          *Corresponding author: Joong Hyun Shim, Tel: 82-43-649-1615, Fax: 82-43-649-1730, E-mail: jhshim@ 123456semyung.ac.kr

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30048-7
          10.1016/S1875-5364(18)30048-7
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Technological Innovation R&D Program
          Award ID: S2443581
          This work was supported by the Technological Innovation R&D Program (No. S2443581) funded by the Small and Medium Business Administration (SMBA, Korea).

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