47
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Susceptibility of Canada Geese ( Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Prior exposure of Canada geese to a North American low pathogenic virus (H5N2) decreases their susceptibility to Eurasian highly pathogenic avian influenza virus (H5N1).

          Abstract

          Migratory birds have been implicated in the long-range spread of highly pathogenic avian influenza (HPAI) A virus (H5N1) from Asia to Europe and Africa. Although sampling of healthy wild birds representing a large number of species has not identified possible carriers of influenza virus (H5N1) into Europe, surveillance of dead and sick birds has demonstrated mute ( Cygnus olor) and whooper ( C. cygnus) swans as potential sentinels. Because of concerns that migratory birds could spread H5N1 subtype to the Western Hemisphere and lead to its establishment within free-living avian populations, experimental studies have addressed the susceptibility of several indigenous North American duck and gull species. We examined the susceptibility of Canada geese ( Branta canadensis) to HPAI virus (H5N1). Large populations of this species can be found in periagricultural and periurban settings and thus may be of potential epidemiologic importance if H5N1 subtype were to establish itself in North American wild bird populations .

          Related collections

          Most cited references18

          • Record: found
          • Abstract: found
          • Article: not found

          Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.

          The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Highly pathogenic H5N1 influenza virus infection in migratory birds.

            H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Predicting the global spread of H5N1 avian influenza.

              The spread of highly pathogenic H5N1 avian influenza into Asia, Europe, and Africa has resulted in enormous impacts on the poultry industry and presents an important threat to human health. The pathways by which the virus has and will spread between countries have been debated extensively, but have yet to be analyzed comprehensively and quantitatively. We integrated data on phylogenetic relationships of virus isolates, migratory bird movements, and trade in poultry and wild birds to determine the pathway for 52 individual introduction events into countries and predict future spread. We show that 9 of 21 of H5N1 introductions to countries in Asia were most likely through poultry, and 3 of 21 were most likely through migrating birds. In contrast, spread to most (20/23) countries in Europe was most likely through migratory birds. Spread in Africa was likely partly by poultry (2/8 introductions) and partly by migrating birds (3/8). Our analyses predict that H5N1 is more likely to be introduced into the Western Hemisphere through infected poultry and into the mainland United States by subsequent movement of migrating birds from neighboring countries, rather than from eastern Siberia. These results highlight the potential synergism between trade and wild animal movement in the emergence and pandemic spread of pathogens and demonstrate the value of predictive models for disease control.
                Bookmark

                Author and article information

                Journal
                Emerg Infect Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                December 2007
                : 13
                : 12
                : 1821-1827
                Affiliations
                [* ]Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada
                []Public Health Agency of Canada, Winnipeg, Manitoba, Canada
                []National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
                [§ ]National Center for Veterinary Diagnosis, Hanoi, Vietnam
                Author notes
                Address for correspondence: John Pasick, National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, 1015 Arlington St, Winnipeg, Manitoba, Canada R3E 3M4; email: jpasick@ 123456inspection.gc.ca
                Article
                07-0502
                10.3201/eid1312.070502
                2876756
                18258030
                acccb710-3b45-4c95-b67b-11a8daa715cd
                History
                Categories
                Research

                Infectious disease & Microbiology
                (h5n1) subtype,pathogenesis,immunity,research,influenza a virus
                Infectious disease & Microbiology
                (h5n1) subtype, pathogenesis, immunity, research, influenza a virus

                Comments

                Comment on this article