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      Norepinephrine, Phentolamine and Buflomedil Influence on Arteriolar Vasomotion in the Hamster Skinfold Preparation

      Journal of Vascular Research

      S. Karger AG

      Norepinephrine, Phentolamine, Buflomedil, Microcirculation, Arteriole, Vasomotion, Skin, Hamster

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          Abstract

          Vasomotion is a potential target for drugs in vascular diseases. In this work, the effects on arteriolar vasomotion of norepinephrine, phentolamine and the vasoactive drug buflomedil were assessed in the hamster skinfold preparation. Results show the strong vaso-kinetic properties of alpha-sympathetic receptor activation by norepinephrine and an expected depressive effect of the alpha-blocker phentolamine. Buflomedil 10<sup>–4</sup> M enhances vasomotion and arteriolar reactivity and does not interfere with norepinephrine. The mechanism of these properties of buflomedil remains to be investigated.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-5491-6
          978-3-318-01136-4
          1018-1172
          1423-0135
          1991
          1991
          23 September 2008
          : 28
          : Suppl 1
          : 33-37
          Affiliations
          Laboratoire d’Hémodynamique Périphérique et de Microcirculation, Centre Hospitalier Universitaire de Grenoble, La Tronche, France
          Article
          158918 Blood Vessels 1991;28:33–37
          10.1159/000158918
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Microvascular Motricity and Haemorheology Effects of Buflomedil

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