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      Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells

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          Abstract

          Three dimensional sub-micron resolution has made two-photon nanomedicine a very promising medical tool for cancer treatment since current techniques cause significant side effects for lack of spatial selectivity. Two-photon-excited (TPE) photodynamic therapy (PDT) has been achieved via mesoporous nanoscaffolds, but the efficiency of the treatment could still be improved. Herein, we demonstrate the enhancement of the treatment efficiency via gold-mesoporous organosilica nanocomposites for TPE-PDT in cancer cells when compared to mesoporous organosilica particles. We performed the first comparative study of the influence of the shape and spatial position of gold nanoparticles (AuNPs) with mesoporous silica nanoparticles (MSN) functionalized with thiol groups and doped with a two-photon electron donor (2PS). The resulting multifunctional nanocarriers displayed TPE-fluorescence and were imaged inside cells. Furthermore, mesoporous organosilica NPs decorated gold nanospheres (AuNSs) induced 63 percent of selective killing on MCF-7 breast cancer cells. This study thus provides insights for the design of more effective multifunctional two-photon-sensitive nanocomposites via AuNPs for biomedical applications.

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          Most cited references35

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          Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery.

          In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano-based targeted cancer therapy and MSN-based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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            Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals.

            Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug-delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin-loaded MSNs. These results indicate that MSNs are biocompatible, preferentially accumulate in tumors, and effectively deliver drugs to the tumors and suppress tumor growth.
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              Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery

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                Author and article information

                Contributors
                Journal
                Front Mol Biosci
                Front Mol Biosci
                Front. Mol. Biosci.
                Frontiers in Molecular Biosciences
                Frontiers Media S.A.
                2296-889X
                03 February 2016
                2016
                : 3
                : 1
                Affiliations
                [1] 1Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France
                [2] 2NanoMedSyn, 2 - Faculté de Pharmacie Montpellier, France
                [3] 3Institut NEEL, CNRS, Université Grenoble Alpes Grenoble, France
                [4] 4Institut Des Sciences Chimiques de Rennes, CNRS UMR 6226 Université Rennes 1 Rennes, France
                [5] 5University of Bordeaux, Institut des Sciences Moléculaires, UMR CNRS 5255 Talence, France
                [6] 6Institut des Biomolécules Max Mousseron UMR 5247 CNRS; UM 1; UM 2 - Faculté de Pharmacie, Université Montpellier Montpellier, France
                Author notes

                Edited by: Angela Tino, National Research Council of Italy CNR, Italy

                Reviewed by: Maria Ada Malvindi, Italian Institute of Technology, Italy; Maria Moros Caballero, Institute of Nanoscience of Aragon, Spain

                *Correspondence: Jonas G. Croissant jonasc@ 123456chem.ucla.edu ;
                Jean-Olivier Durand durand@ 123456um2.fr

                This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Molecular Biosciences

                Article
                10.3389/fmolb.2016.00001
                4737918
                26870736
                acdd69a6-5662-4435-b681-76ec9990c971
                Copyright © 2016 Croissant, Qi, Maynadier, Cattoën, Wong Chi Man, Raehm, Mongin, Blanchard-Desce, Garcia, Gary-Bobo and Durand.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 17 November 2015
                : 14 January 2016
                Page count
                Figures: 9, Tables: 0, Equations: 0, References: 38, Pages: 9, Words: 5448
                Categories
                Bioengineering and Biotechnology
                Original Research

                two-photon,gold nanoparticles,organic-inorganic,photodynamic therapy,mesoporous silica nanoparticles

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