A preliminary analysis of blood hemogram variation in 45 cases of COVID-19 patients before and after treatment

Abstract

Objective To observe the blood hemogram variation of coronavirus disease 2019 (COVID-19) patients, so as to study the correlation between the changes of blood hemogram and the therapeutic effect of the patients.

Methods The blood hemogram variation of 45 cases COVID-19 patients before and after treatment were retrospectively analyzed. The therapeutic effect was divided into groups for comparative analysis.

Results Before 45 cases of COVID-19 patients were treated, the neutrophil percentage was raising 60% (27/45), the eosinophil absolute value was declining 93.3% (42/45), and eosinophil percentage was declining 93.3% (42 / 45), the absolute value of lymphocyte was declining 77.8% (35 / 45), the percentage of lymphocyte was declining 64.4% (29/45), and the whole C-reactive protein was raising 86.7% (39/45). After 45 COVID-19 patients were treated, lymphocyte absolute value was declining 55.6% (25/45), the percentage of lymphocyte was declining 55.6% (25/45), the whole C-reactive protein was raising 57.8% (26/45). The comparison results by chi-square test showed that there were no significant differences in the leukocyte count, neutrophil absolute value, eosinophil percentage and lymphocyte absolute value between the improvement group and the non-improvement group before and after treatment. The percentage of neutrophils, the absolute value of eosinophils, the absolute value of eosinophils and the whole C-reactive protein were significantly different between the improvement group and the non-improvement group before and after treatment.

Conclusion In the COVID-19 patients, the white blood cell count and neutrophil absolute value were in more normal intervals. The percentage of neutrophils increased earlier and returned to normal after treatment. The absolute value of eosinophils decreased earlier and returned to normal after treatment. The absolute value of lymphocyte and absolute value of lymphocyte decreased significantly, and the whole course of C reactive protein increased. The percentage of neutrophils, the absolute value of eosinophils, the absolute value of eosinophils and the whole course C-reactive protein in the hemogram were positively correlated with the treatment outcome of COVID-19.

Abstract

摘要：目的 通过观察新型冠状病毒肺炎患者血象变化，从而研究血象变化与患者治疗疗效的关联 。方法 回顾 性分析45例新型冠状病毒肺炎患者治疗前后血象指标变化，以治疗疗效情况分组进行对比分析。 结果 45例新型冠 状病毒肺炎患者治疗前血象中中性粒细胞百分比60.0%(27/45)升高，嗜酸性粒细胞绝对值93.3%(42/45)降低，嗜酸性 粒细胞百分比93.3%(42/45)降低，淋巴细胞绝对值77.8%(35/45)降低，淋巴细胞百分比64.4%(29/45)降低，全程C反应 蛋白86.7%(39/45)升高。45例新型冠状病毒肺炎患者治疗后血象中淋巴细胞绝对值55.6%(25/45)降低、淋巴细胞百 分比55.6%(25/45)降低、全程C反应蛋白57.8%(26/45)升高。采用f检验比较：好转组与未见好转组患者治疗前后血 象中白细胞计数、中性粒细胞绝对值、嗜酸性粒细胞百分比、淋巴细胞绝对值差异无统计学意义。好转组与未见好转 组患者治疗前后血象中中性粒细胞百分比、嗜酸性粒细胞绝对值、嗜酸性粒细胞百分比、全程C反应蛋白有统计学意 义。 结论 新型冠状病毒肺炎患者血象中白细胞计数、中性粒细胞绝对值多正常区间变化；中性粒细胞百分比前期多 升高，治疗后多在恢复正常;嗜酸性粒细胞绝对值前期下降，治疗后多恢复正常；淋巴细胞绝对值、淋巴细胞百分比下 降明显；全程C反应蛋白多升高。血象中中性粒细胞百分比、嗜酸性粒细胞绝对值、嗜酸性粒细胞百分比、全程C反应 蛋白与新型冠状病毒肺炎治疗转归呈正相关。