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      Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces

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      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          <p class="first" id="d9640232e59">Self-assembled monolayers (SAMs) of omega-functionalized long-chain alkanethiolates on gold films are excellent model systems with which to study the interactions of proteins with organic surfaces. Monolayers containing mixtures of hydrophobic (methyl-terminated) and hydrophilic [hydroxyl-, maltose-, and hexa(ethylene glycol)-terminated] alkanethiols can be tailored to select specific degrees of adsorption: the amount of protein adsorbed varies monotonically with the composition of the monolayer. The hexa(ethylene glycol)-terminated SAMs are the most effective in resisting protein adsorption. The ability to create interfaces with similar structures and well-defined compositions should make it possible to test hypotheses concerning protein adsorption. </p>

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          May 24 1991
          May 24 1991
          : 252
          : 5009
          : 1164-1167
          Article
          10.1126/science.252.5009.1164
          2031186
          ad12e4c4-7aa9-43b8-bb7a-582adedce010
          © 1991
          History

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