Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats.

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Abstract

Feline chronic kidney disease (CKD) is characterized by chronic tubulointerstitial nephritis, and inflammation contributes to the progression of renal fibrosis. Mesenchymal stem cells (MSCs) have demonstrated anti-inflammatory and antifibrotic effects in rodent CKD models. However, few randomized trials evaluating the effectiveness of MSC therapy for diseases in companion animals have been reported. The purpose of this study was to evaluate the effectiveness of allogeneic MSCs for the treatment of feline CKD using a randomized, placebo-controlled trial.

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Journal

Journal ID (iso-abbrev): J. Feline Med. Surg.

Title: Journal of feline medicine and surgery

Publisher: SAGE Publications

ISSN (Electronic): 1532-2750

ISSN (Print): 1098-612X

Publication date (Electronic): Feb 2016

Volume: 18

Issue: 2

Affiliations

[1 ] Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA jquimby@colostate.edu.

[2 ] Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.

[3 ] Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

[4 ] Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA Current address: AV Veterinary Radiology, Denver, CO 80202, USA.

[5 ] Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Article

Publisher Item ID: 1098612X15576980

DOI: 10.1177/1098612X15576980

PubMed ID: 25784460

SO-VID: ad26a3c0-f024-4f10-a8c1-aa6323093ac2

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