Effect of Age on Blood Pressure and Small Vessel Reactivity in Male Rabbits

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Abstract

Direct blood pressure measurements were made on male rabbits from 3 to 55 months old to determine if blood pressure increases with age in this animal model as it does in humans. To assess the effects of age on vascular reactivity, strips of small ear artery and skeletal muscle artery were taken from these animals and tested with norepinephrine, potassium, histamine, and isoproterenol in vitro. Heart rate did not differ between age groups, but blood pressure was significantly higher in older age groups compared to 3-month-old rabbits. Vessels from older animals were thicker and less sensitive to norepinephrine. Responses to potassium, histamine, and isoproterenol were not different between age groups. The results suggest that male rabbits offer a good model of age-related increases in blood pressure, and that changes in vascular adrenergic rectivity may occur with age in male rabbits.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1986

Publication date (Print): 1986

Publication date (Electronic): 23 September 2008

Volume: 23

Issue: 6

Pages: 271-278

Affiliations

Department of Biological Sciences, Northern Arizona University, Flagstaff, Ariz., USA

Article

Publisher ID: 158654 Other ID: Blood Vessels 1986;23:271–278

DOI: 10.1159/000158654

SO-VID: ad2c56f4-26ae-49bb-8eb4-d324a144859d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 13 June 1985

Date accepted : 13 May 1986

Page count

Pages: 8

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