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      Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.

      Science (New York, N.Y.)

      therapeutic use, Anti-HIV Agents, Antigens, Viral, immunology, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Drug Therapy, Combination, HIV Infections, drug therapy, HIV Protease Inhibitors, administration & dosage, HIV-1, drug effects, physiology, Homeostasis, Humans, Adult, Immunologic Memory, Lymphocyte Activation, Lymphocyte Count, Middle Aged, RNA, Viral, blood, Reverse Transcriptase Inhibitors, Ritonavir, T-Lymphocyte Subsets, Tuberculin, Viral Load, Viremia, Zalcitabine, Zidovudine

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          Abstract

          Highly active antiretroviral therapy (HAART) increases CD4(+) cell numbers, but its ability to correct the human immunodeficiency virus (HIV)-induced immune deficiency remains unknown. A three-phase T cell reconstitution was demonstrated after HAART, with: (i) an early rise of memory CD4(+) cells, (ii) a reduction in T cell activation correlated to the decreasing retroviral activity together with an improved CD4(+) T cell reactivity to recall antigens, and (iii) a late rise of "naïve" CD4(+) lymphocytes while CD8(+) T cells declined, however, without complete normalization of these parameters. Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients.

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          9204894

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