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      From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

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      Cell

      Elsevier BV

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          Abstract

          A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          June 2016
          June 2016
          : 165
          : 6
          : 1332-1345
          Article
          10.1016/j.cell.2016.05.041
          27259147
          © 2016

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