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      Melatonin Concentrations in Human Serum, Ventricular and Lumbar Cerebrospinal Fluids as an Index of the Secretory Pathway of the Pineal Gland

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Serum, Secretory pathway, Melatonin, Radioimmunoassay, Lumbar CSF, Ventricular CSF

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          Abstract

          Melatonin was extracted from human sera, ventricular and lumbar cerebrospinal fluids taken within an hour from 25 patients undergoing neurosurgical operations such as ventricular shunts and craniotomy. Using a radioimmunoassay procedure, it was possible to measure the melatonin concentrations in 3 groups of patients: (a) those with obstructive hydrocephalus, (b) those with communicating hydrocephalus, and (c) those with normal cerebrospinal fluid flow. It was demonstrated that melatonin levels were higher in sera compared with those in lumbar and ventricular cerebrospinal fluids thus supporting the view that melatonin is primarily secreted into the bloodstream.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 4
          : 224-233
          Affiliations
          Department of Biochemistry, Faculty of Medicine, National University of Singapore, and Neurological Surgery, Mount Elizabeth Medical Centre, Mount Elizabeth, Singapore
          Article
          179392 Horm Res 1981;14:224–233
          10.1159/000179392
          7308980
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Original Paper

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