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      Melatonin Concentrations in Human Serum, Ventricular and Lumbar Cerebrospinal Fluids as an Index of the Secretory Pathway of the Pineal Gland


      Hormone Research in Paediatrics

      S. Karger AG

      Serum, Secretory pathway, Melatonin, Radioimmunoassay, Lumbar CSF, Ventricular CSF

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          Melatonin was extracted from human sera, ventricular and lumbar cerebrospinal fluids taken within an hour from 25 patients undergoing neurosurgical operations such as ventricular shunts and craniotomy. Using a radioimmunoassay procedure, it was possible to measure the melatonin concentrations in 3 groups of patients: (a) those with obstructive hydrocephalus, (b) those with communicating hydrocephalus, and (c) those with normal cerebrospinal fluid flow. It was demonstrated that melatonin levels were higher in sera compared with those in lumbar and ventricular cerebrospinal fluids thus supporting the view that melatonin is primarily secreted into the bloodstream.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 14
          : 4
          : 224-233
          Department of Biochemistry, Faculty of Medicine, National University of Singapore, and Neurological Surgery, Mount Elizabeth Medical Centre, Mount Elizabeth, Singapore
          179392 Horm Res 1981;14:224–233
          © 1981 S. Karger AG, Basel

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          Pages: 10
          Original Paper


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