Factors That Determine Cell-Specific Gene Expression in Pancreatic Endocrine Tumor Cells

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Abstract

Phenotypically distinct islet tumor cell lines may recapitulate certain of the developmental pathways of normal islet cell differentiation by expressing a combinatorial set of positively and negatively acting DNA-binding proteins to allow for the programmed expression of genes encoding polypeptide hormones. The structure of one of these DNA-binding proteins, a cyclic AMP-responsive protein (CREB) that binds specific DNA regulatory elements in the somatostatin gene, has been deduced from the sequence of a cloned cDNA. The CREB protein contains a DNA-binding domain separate from a cAMP-dependent protein kinase A activation domain. Further characterizations of the genes encoding the DNA-binding proteins should help to elucidate the cellular processes involved in islet cell differentiation and the genesis of tumors.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5167-0

ISBN: 978-3-318-01959-9

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 02 December 2008

Volume: 32

Issue: 1-3

Pages: 61-66

Affiliations

Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass., USA

Article

Publisher ID: 181246 Other ID: Horm Res 1989;32:61–66

DOI: 10.1159/000181246

PubMed ID: 2559019

SO-VID: ad6ea359-d823-4c36-b334-d5a0d5ca2783

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Factors That Determine Cell-Specific Gene Expression in Pancreatic Endocrine Tumor Cells

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Karger: Endocrinology

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