13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention.

      Nature reviews. Cancer
      Animals, Humans, Neoplasms, drug therapy, genetics, metabolism, prevention & control, Peroxisome Proliferator-Activated Receptors, agonists

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation and differentiation. Although all of these functions might contribute to the influence of PPARs in carcinogenesis, there is a distinct need for a review of the literature and additional experimentation to determine the potential for targeting PPARs for cancer therapy and cancer chemoprevention. As PPAR agonists include drugs that are used for the treatment of metabolic diseases, a more complete understanding of the roles of PPARs in cancer will aid in determining any increased cancer risk for patients undergoing therapy with PPAR agonists.

          Related collections

          Author and article information

          Journal
          22318237
          3322353
          10.1038/nrc3214

          Chemistry
          Animals,Humans,Neoplasms,drug therapy,genetics,metabolism,prevention & control,Peroxisome Proliferator-Activated Receptors,agonists

          Comments

          Comment on this article