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      Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM.

      Author(s): 1 , 2 , 3 , 4 , 5 , 6 , 6 , 6 , 2 , 7 , 8 , 7 , 9 , 7 , 10 , 7 , 11 , 12 , 13 , 13 , 7 , 14
      Publication date (Electronic):
      Journal: The Journal of allergy and clinical immunology
      Keywords: BM, Bone marrow, CLMast, Hymenoptera, ISM, ISMs(+), ISMs(−), Indolent systemic mastocytosis, Indolent systemic mastocytosis with skin lesions, Indolent systemic mastocytosis without skin lesions, Instituto de Estudios de Mastocitosis de Castilla La Mancha, The Clinical Reference Centre of the Spanish Network on Mastocytosis (REMA) , MC, MCAS, Mast cell, Mast cell activation syndrome, REMA, SM, Serum baseline tryptase, Spanish Network on Mastocytosis, Systemic mastocytosis, VIT, Venom immunotherapy, WHO, World Health Organization, anaphylaxis, insect, insect sting anaphylaxis, mastocytosis, sBT

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          Abstract

          Indolent systemic mastocytosis (ISM) without skin lesions (ISMs(-)) shows a higher prevalence in males, lower serum baseline tryptase levels, and KIT mutation more frequently restricted to bone marrow (BM) mast cells (MCs) than ISM with skin lesions (ISMs(+)). Interestingly, in almost one-half of ISMs(-) patients, MC-mediator release episodes are triggered exclusively by insects.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J. Allergy Clin. Immunol.
          Title: The Journal of allergy and clinical immunology
          ISSN (Electronic): 1097-6825
          ISSN (Print): 0091-6749
          Publication date (Electronic): Feb 2014
          Volume: 133
          Issue: 2
          Affiliations
          [1 ] Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital Virgen del Valle, Toledo, Spain; Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain. Electronic address: ivana@sescam.jccm.es.
          [2 ] Section of Haematology, Department of Medicine, University of Verona, Verona, Italy; Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy.
          [3 ] Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain; Allergy Unit, Hospital de Fuenlabrada, Madrid, Spain.
          [4 ] Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy; Allergy Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
          [5 ] Allergy Department, Hospital de Guadalajara, Guadalajara, Spain.
          [6 ] Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital Virgen del Valle, Toledo, Spain; Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain.
          [7 ] Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain; Centro de Investigación del Cáncer/IBMCC (USAL/CSIC) and IBSAL, Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca, Spain.
          [8 ] Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy; Clinical Chemistry and Haematology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
          [9 ] Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy; Section of Rheumatology, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
          [10 ] Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy; Section of Dermatology, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
          [11 ] Multidisciplinary Outpatients Clinics for Mastocytosis, Verona, Italy; Department of Pathology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
          [12 ] Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain; Pathology Department, Hospital Virgen de la Salud, Toledo, Spain.
          [13 ] Allergy Unit, Hospital Virgen del Valle, Toledo, Spain.
          [14 ] Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain.
          Article
          Publisher Item ID: S0091-6749(13)00988-3
          DOI: 10.1016/j.jaci.2013.06.020
          PubMed ID: 23921094
          SO-VID: ad7d5224-9b09-4df8-9b6d-72090037d193
          Copyright © Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
          History

          Keywords: BM,Bone marrow,CLMast,Hymenoptera,ISM,ISMs(+),ISMs(−),Indolent systemic mastocytosis,Indolent systemic mastocytosis with skin lesions,Indolent systemic mastocytosis without skin lesions,Instituto de Estudios de Mastocitosis de Castilla La Mancha, The Clinical Reference Centre of the Spanish Network on Mastocytosis (REMA),MC,MCAS,Mast cell,Mast cell activation syndrome,REMA,SM,Serum baseline tryptase,Spanish Network on Mastocytosis,Systemic mastocytosis,VIT,Venom immunotherapy,WHO,World Health Organization,anaphylaxis,insect,insect sting anaphylaxis,mastocytosis,sBT
          Data availability:
          Keywords: BM, Bone marrow, CLMast, Hymenoptera, ISM, ISMs(+), ISMs(−), Indolent systemic mastocytosis, Indolent systemic mastocytosis with skin lesions, Indolent systemic mastocytosis without skin lesions, Instituto de Estudios de Mastocitosis de Castilla La Mancha, The Clinical Reference Centre of the Spanish Network on Mastocytosis (REMA), MC, MCAS, Mast cell, Mast cell activation syndrome, REMA, SM, Serum baseline tryptase, Spanish Network on Mastocytosis, Systemic mastocytosis, VIT, Venom immunotherapy, WHO, World Health Organization, anaphylaxis, insect, insect sting anaphylaxis, mastocytosis, sBT

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