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      Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels.

      Life Sciences

      9,10-Dimethyl-1,2-benzanthracene, Animals, Castration, Drug Evaluation, Preclinical, Estradiol, pharmacology, Estrogen Antagonists, therapeutic use, Female, Luteinizing Hormone, blood, secretion, Mammary Neoplasms, Experimental, physiopathology, Piperidines, Prolactin, Raloxifene, Rats, Rats, Inbred Strains, Tamoxifen

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          Abstract

          Keoxifene (LY156758) is a new benzothiophene-derived antiestrogen with an extremely low degree of estrogenicity. Administration of 1-20 mg/kg per day inhibited the growth of 7, 12-dimethylbenzanthracene (DMBA)-induced mammary tumors in rats. The degree of inhibition of mammary tumor growth was similar to that observed with tamoxifen treatment.

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          6406781

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