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Psoriatic architecture constructed by epidermal remodeling.

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      Abstract

      Epidermal remodeling is the concept that epidermal architecture is determined by a simple self-organizing mechanism; epidermal hyperproliferation constructs typical psoriatic architecture. This is based on the assumption that the enlargements in both the two-dimensional proliferative compartment (basal cell layer) and three-dimensional whole epidermal volume coexist. During this process, the dermal papillae become markedly, but passively, expanded by enlargement of the proliferative compartment. This creates a considerable shrinkage force against the crowded basal cell layer, which is forced to lose adherence to the dermal extracellular matrix (ECM). This results in anoikis, a type of apoptosis characterized by cell detachment, and, consequently, a markedly diminished epidermal turnover time in psoriasis. The papillary shrinkage force also explains the fact that dermal papillary height does not exceed a certain limit. At the cessation of hyperproliferation a normalisation remodeling takes place toward normal tissue architecture. Thus the concept of epidermal remodeling explains the self-organizing mechanism of the architectural change in psoriasis, which is essentially a reversible disorder depending on epidermal hyperproliferation.

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      Affiliations
      [1 ] Department of Dermatology, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1, Asahikawa, Japan. derma@mail.asahikawa-med.ac.jp
      Journal
      J. Dermatol. Sci.
      Journal of dermatological science
      Elsevier BV
      0923-1811
      0923-1811
      Aug 2004
      : 35
      : 2
      15265521
      10.1016/j.jdermsci.2004.01.003
      S0923181104000064

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