Language Impairment and Rate of Cognitive Decline in Alzheimer's Disease

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Abstract

There is growing evidence that AD consists of different subtypes, and that language is a pertinent factor to identify a subgroup with a fast rate of cognitive decline. We report the first results of a longitudinal study in which we compared two groups of patients with probable AD. The main result showed that a subgroup with stable MMSE scores during a 1-year follow-up period had an impairment in language domains which are usually preserved until an advanced stage of the disease. It is proposed that this group may correspond to a variety of AD who, in addition to symptoms of AD, present characteristics of primary progressive aphasia. In other respects, we underscore that the high loading in language-mediated tasks of the MMSE makes it a poor index to accurately measure the rate of cognitive decline.

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Journal ID (publisher-id): DEM

Journal ID (nlm-ta): Dement Geriatr Cogn Disord

Journal ID (doi): 10.1159/issn.1420-8008

Title: Dementia and Geriatric Cognitive Disorders

Publisher: S. Karger AG

ISSN (Print): 1420-8008

ISSN (Electronic): 1421-9824

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 02 November 1994

Volume: 5

Issue: 6

Pages: 334-338

Affiliations

Unité de Neuropsychologie et Neurobiologie du Vieillissement Cérébral, U. 324 – INSERM – Centre Paul Broca, Paris, France

Article

Publisher ID: 106743 Other ID: Dement Geriatr Cogn Disord 1994;5:334–338

DOI: 10.1159/000106743

SO-VID: ad9c7c0f-0ceb-4458-a3a9-7b11661fffcd

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Language Impairment and Rate of Cognitive Decline in Alzheimer's Disease

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Karger: Neurology and Neuroscience

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