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      Language Impairment and Rate of Cognitive Decline in Alzheimer's Disease

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          There is growing evidence that AD consists of different subtypes, and that language is a pertinent factor to identify a subgroup with a fast rate of cognitive decline. We report the first results of a longitudinal study in which we compared two groups of patients with probable AD. The main result showed that a subgroup with stable MMSE scores during a 1-year follow-up period had an impairment in language domains which are usually preserved until an advanced stage of the disease. It is proposed that this group may correspond to a variety of AD who, in addition to symptoms of AD, present characteristics of primary progressive aphasia. In other respects, we underscore that the high loading in language-mediated tasks of the MMSE makes it a poor index to accurately measure the rate of cognitive decline.

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          Dement Geriatr Cogn Disord
          Dementia and Geriatric Cognitive Disorders
          S. Karger AG
          02 November 1994
          : 5
          : 6
          : 334-338
          Unité de Neuropsychologie et Neurobiologie du Vieillissement Cérébral, U. 324 – INSERM – Centre Paul Broca, Paris, France
          106743 Dement Geriatr Cogn Disord 1994;5:334–338
          © 1994 S. Karger AG, Basel

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          Pages: 5
          Original Research Article


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