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      Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.

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          Abstract

          To investigate the mechanism underlying anti-inflammatory and immunoregulatory effect of total glucosides of paeony (TGP) based on toll-like receptor 2 (TLR2) mediated tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/nuclear factor-kappa B (NF-κB) pathway activation in rats with rheumatoid arthritis.

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          Author and article information

          Journal
          J Tradit Chin Med
          Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
          2589-451X
          0255-2922
          August 2019
          : 39
          : 4
          Affiliations
          [1 ] Institute of Meterial Medica Integration and Transformation for Brain Disorders, CDUTCM, Chengdu 610075, China.
          [2 ] Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
          Article
          2944
          32186105
          adac27f1-60a8-4adb-9930-0395e5b8a369
          History

          Arthritis, rheumatoid,Total glucosides of paeony,Transcription factor RelA,Toll-like receptor 2,Arthritis, experimental,CD4-CD8 ratio,Fas ligand protein,TNF receptor-associated factor 6

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