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Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures.
Shuang Hou
1 ,
Haichao Zhao ,
Libo Zhao ,
Qinglin Shen ,
Kevin S Wei ,
Daniel Y Suh ,
Aiko Nakao ,
Mitch A Garcia ,
Min Song ,
Tom Lee ,
Bin Xiong ,
Shyh-Chyang Luo ,
Hsian-Rong Tseng ,
Hsiao-hua Yu
Mar 20 2013
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Abstract
A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.