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      Processing, signaling, and physiological function of chemerin.

      1 , ,
      IUBMB life
      Wiley
      CMKLR1, chemerin, inflammation, obesity, psoriasis, skin

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          Abstract

          Chemerin is an immunomodulating factor secreted predominantly by adipose tissue and skin. Processed by a variety of proteases linked to inflammation, it activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells. Recent developments revealed the role of the nonsignaling chemerin receptor C-C chemokine receptor-like 2 (CCRL2) in inflammation. Besides further research establishing its link to inflammatory skin conditions such as psoriasis, functions in healthy skin have also been reported. Here, the current understanding of chemerin processing, signaling and physiological function has been summarized, focusing on the regulation of its activity, its different receptors and its controversially discussed role in diseases.

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          Author and article information

          Journal
          IUBMB Life
          IUBMB life
          Wiley
          1521-6551
          1521-6543
          Jan 2014
          : 66
          : 1
          Affiliations
          [1 ] Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Universität Leipzig, Leipzig, Germany.
          Article
          10.1002/iub.1242
          24446308
          adc79f8e-7d90-4f5c-b842-be030bb7a4f8
          © 2014 International Union of Biochemistry and Molecular Biology.
          History

          CMKLR1,chemerin,inflammation,obesity,psoriasis,skin
          CMKLR1, chemerin, inflammation, obesity, psoriasis, skin

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