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      Circulating LH, FSH, Prolactin, Testosterone, ▵4-Androstenedione, Dehydroepiandrosterone Sulfate and Cortisol Levels in the Fetus in Late Gestation and in Newborn Male and Female Lambs

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          Gonadotropins, prolactin (PRL), testosterone (T), Δ<sub>4</sub>-androstenedione, dehydroepiandrosterone sulfate and cortisol (F) levels were determined from 14 days before birth to term in 3 female and 3 male ovine fetuses with a chronically implanted venous catheter, and in the same animals from birth to 72 h of age. In both sexes, plasma gonadotropins and androgens were low throughout the period of study while plasma F increased with gestational age. After birth, plasma gonadotropins and PRL tended to increase progressively with time while PRL concentrations were significantly higher in female than in male lambs. F and T concentrations decreased significantly within the first 12 and 6 h of postnatal life. Higher T values were again observed at 36 h in male lambs. These data indicate that the fetal hypothalamic-pituitary-gonadal axis is relatively quiescent in the last 14 days of gestation but is activated within the first 72 h after birth.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 15
          : 2
          : 122-132
          aEndocrine Laboratory, Centre de Recherche Pédiatrique, Hôpital Sainte-Justine; bINRS-Santé, Montréal, P.Q., Canada; clnserm U-34 et dU-162, Lyon, France
          179441 Horm Res 1981;15:122–132
          © 1981 S. Karger AG, Basel

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          Pages: 11
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