Early Fractures and Occult Hyperthyroidism: McCune-Albright Syndrome?

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Abstract

McCune-Albright syndrome (MAS) is a sporadic disease characterized by fibrous bone dysplasia, café-au-lait spots and hyperfunctional endocrinopathies. We report a 2.5-year-old child with MAS with an early and nonclassic onset. He was admitted to our attention for frequent fractures without clinical signs of endocrinopathies, found to have asymptomatic, nonautoimmune hyperthyroidism. The diagnosis of MAS was based on RX and MR imaging associated with hyperthyroidism. It is not clear if there was a correlation between the severity of bone disease and the presence of thyroid disorder. At the moment no standard treatment exists for bone fibrous dysplasia and hyperthyroidism in children before the age of 6 years.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 2001

Publication date (Print): 2001

Publication date (Electronic): 31 January 2002

Volume: 56

Issue: 1-2

Pages: 58-62

Affiliations

Departments of ^aPediatrics, endocrine unit, and ^bOrthopedics, Scientific Institute H.S. Raffaele, University of Milan, Italy

Article

Publisher ID: 48091 Other ID: Horm Res 2001;56:58–62

DOI: 10.1159/000048091

PubMed ID: 11815729

SO-VID: add4b3a3-3639-41cf-add7-571aef978719

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Early Fractures and Occult Hyperthyroidism: McCune-Albright Syndrome?

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Karger: Endocrinology

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