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      Early Fractures and Occult Hyperthyroidism: McCune-Albright Syndrome?

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          McCune-Albright syndrome (MAS) is a sporadic disease characterized by fibrous bone dysplasia, café-au-lait spots and hyperfunctional endocrinopathies. We report a 2.5-year-old child with MAS with an early and nonclassic onset. He was admitted to our attention for frequent fractures without clinical signs of endocrinopathies, found to have asymptomatic, nonautoimmune hyperthyroidism. The diagnosis of MAS was based on RX and MR imaging associated with hyperthyroidism. It is not clear if there was a correlation between the severity of bone disease and the presence of thyroid disorder. At the moment no standard treatment exists for bone fibrous dysplasia and hyperthyroidism in children before the age of 6 years.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          31 January 2002
          : 56
          : 1-2
          : 58-62
          Departments of aPediatrics, endocrine unit, and bOrthopedics, Scientific Institute H.S. Raffaele, University of Milan, Italy
          48091 Horm Res 2001;56:58–62
          © 2002 S. Karger AG, Basel

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