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      Nephrotoxicity Associated with Use of Methoxyflurane

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          Abstract

          Two cases of severe renal failure associated with the use of methoxyflurane anesthesia are reported. Both patients had polyuria during the immediate period after anesthesia and 7–10 days later became oliguric. After 26–31 days, a diuresis occurred with very slow recovery of adequate but reduced renal function. One case demonstrated hypernatremia and hyperosmolality. The development of renal failure did not depend upon a prolonged period of anesthesia. In one case, a renal biopsy revealed tubular epithelial cell degeneration, necrosis, and atrophy and crystals resembling calcium oxalate. Multiple mechanisms which may contribute to the development of renal failure associated with methoxyflurane are discussed. Supportive therapy, including dialysis, seems warranted to allow adequate time for return of renal function.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 2
          : 174-182
          Affiliations
          Medical and Research Services, Veterans Administration Wadsworth Hospital Center, Wilshire and Sawtelle Blvds. and Department of Medicine, UCLA School of Medicine, Los Angeles, Calif.
          Article
          180390 Nephron 1974;13:174–182
          10.1159/000180390
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Case Report

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