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      Risk factors for disruptive behaviours: protocol for a systematic review and meta-analysis of quasi-experimental evidence

      systematic-review

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          Abstract

          Introduction

          Disruptive behaviour disorders, including oppositional defiant disorder and conduct disorder, are a common set of diagnoses in childhood and adolescence, with global estimates of 5.7%, 3.6% and 2.1% for any disruptive disorder, oppositional defiant disorder and conduct disorder, respectively. There are high economic and social costs associated with disruptive behaviours and the prevalence of these disorders has increased in recent years. As such, disruptive behaviours represent an escalating major public health concern and it is important to understand what factors may influence the risk of these behaviours. Such research would inform interventions that aim to prevent the development of disruptive behaviours. The current review will identify the most stringent evidence of putative risk factors for disruptive behaviour from quasi-experimental studies, which enable stronger causal inference.

          Methods and analysis

          The review will be carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. An electronic search of references published between 1 January 1980 and 1 March 2020 will be conducted using Medline, Embase, PsycINFO and Web of Science. Initial abstract and title screening, full-text screening and data extraction will be completed independently by two reviewers using Evidence for Policy and Practice Information (EPPI)-Reviewer 4 software. Quasi-experimental studies in the English language examining the association between any putative risk factor and a clearly defined measure of disruptive behaviour (eg, a validated questionnaire measure) will be included. We will conduct meta-analyses if we can pool a minimum of three similar studies with the same or similar exposures and outcomes.

          Ethics and dissemination

          The proposed review does not require ethical approval. The results will help to identify risk factors for which there is strong evidence of causal effects on disruptive behaviours and also highlight potential risk factors that require further research. The findings will be disseminated via publication in a peer-reviewed scientific journal and through presentations at international meetings and conferences.

          PROSPERO registration number

          CRD42020169313.

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          Most cited references24

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          Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation

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            Conducting Meta-Analyses inRwith themetaforPackage

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              Annual research review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents.

              The literature on the prevalence of mental disorders affecting children and adolescents has expanded significantly over the last three decades around the world. Despite the field having matured significantly, there has been no meta-analysis to calculate a worldwide-pooled prevalence and to empirically assess the sources of heterogeneity of estimates.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2020
                9 September 2020
                : 10
                : 9
                Affiliations
                [1 ]departmentGreat Ormond Street Institute of Child Health , University College London , London, UK
                [2 ]departmentDivision of Psychiatry , University College London , London, UK
                [3 ]departmentDepartment of Psychology , University of Pennsylvania , Philadelphia, Pennsylvania, USA
                [4 ]departmentDepartment of Clinical, Educational and Health Psychology , University College London , London, UK
                [5 ]departmentSocial, Genetic, and Developmental Psychiatry , King’s College London , London, UK
                Author notes
                [Correspondence to ] Ms Lucy Karwatowska; lucy.karwatowska.18@ 123456ucl.ac.uk
                Article
                bmjopen-2020-038258
                10.1136/bmjopen-2020-038258
                7482491
                ae05502d-dcd2-4f6f-bb7e-68bc4f8f3b9e
                © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

                This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:  https://creativecommons.org/licenses/by/4.0/.

                Product
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000269, Economic and Social Research Council;
                Award ID: ES/P000347/1
                Categories
                Mental Health
                1506
                1712
                Protocol
                Custom metadata
                unlocked

                Medicine
                child & adolescent psychiatry,personality disorders,statistics & research methods,epidemiology

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