For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
43
views
53
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      382
      similar
       All similar

      Patient Preference and Adherence (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the growing importance of patient preference and adherence throughout the therapeutic process. Sign up for email alerts here.

      34,896 Monthly downloads/views I 2.314 Impact Factor I 3.8 CiteScore I 1.14 Source Normalized Impact per Paper (SNIP) I 0.629 Scimago Journal & Country Rank (SJR)

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Association between addressing antiseizure drug side effects and patient-reported medication adherence in epilepsy

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background and aim

          Adherence to treatment is a critical component of epilepsy management. This study examines whether addressing antiepileptic drug (AED) side effects at every visit is associated with increased patient-reported medication adherence.

          Patients and methods

          This study identified 243 adults with epilepsy who were seen at two academic outpatient neurology settings and had at least two visits over a 3-year period. Demographic and clinical characteristics were abstracted. Evidence that AED side effects were addressed was measured through 1) phone interview (patient-reported) and 2) medical records abstraction (physician-documented). Medication adherence was assessed using the validated Morisky Medication Adherence Scale-4. Complete adherence was determined as answering “no” to all questions.

          Results

          Sixty-two (25%) patients completed the interviews. Participants and nonparticipants were comparable with respect to demographic and clinical characteristics; however, a smaller proportion of participants had a history of drug-resistant epilepsy than nonparticipants (17.7% vs 30.9%, P=0.04). Among the participants, evidence that AED side effects were addressed was present in 48 (77%) medical records and reported by 51 (82%) patients. Twenty-eight (45%) patients reported complete medication adherence. The most common reason for incomplete adherence was missed medication due to forgetfulness (n=31, 91%). There was no association between addressing AED side effects (neither physician-documented nor patient-reported) and complete medication adherence ( P=0.22 and 0.20).

          Discussion and conclusion

          Among patients with epilepsy, addressing medication side effects at every visit does not appear to increase patient-reported medication adherence.

          Most cited references53

          • Record: found
          • Abstract: found
          • Article: not found

          Concurrent and predictive validity of a self-reported measure of medication adherence.

          D E Morisky, L Green, D Levine (1986)
          Adherence to the medical regimen continues to rank as a major clinical problem in the management of patients with essential hypertension, as in other conditions treated with drugs and life-style modification. This article reviews the psychometric properties and tests the concurrent and predictive validity of a structured four-item self-reported adherence measure (alpha reliability = 0.61), which can be easily integrated into the medical visit. Items in the scale address barriers to medication-taking and permit the health care provider to reinforce positive adherence behaviors. Data on patient adherence to the medical regimen were collected at the end of a formalized 18-month educational program. Blood pressure measurements were recorded throughout a 3-year follow-up period. Results showed the scale to demonstrate both concurrent and predictive validity with regard to blood pressure control at 2 years and 5 years, respectively. Seventy-five percent of the patients who scored high on the four-item scale at year 2 had their blood pressure under adequate control at year 5, compared with 47% under control at year 5 for those patients scoring low (P less than 0.01).
          Article 0 comments Cited 785 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Recommendations for optimal ICD codes to study neurologic conditions: a systematic review.

            Amy Metcalfe, Jane McChesney, J. Roberts … (2012)
            Administrative health data are frequently used for large population-based studies. However, the validity of these data for identifying neurologic conditions is uncertain. This article systematically reviews the literature to assess the validity of administrative data for identifying patients with neurologic conditions. Two reviewers independently assessed for eligibility all abstracts and full-text articles identified through a systematic search of Medline and Embase. Study data were abstracted on a standardized abstraction form to identify ICD code-based case definitions and corresponding sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs). Thirty full-text articles met the eligibility criteria. These included 8 studies for Alzheimer disease/dementia (sensitivity: 8-86.5, specificity: 56.3-100, PPV: 60-97.9, NPV: 68.0-98.9), 2 for brain tumor (sensitivity: 54.0-100, specificity: 97.0-99.0, PPV: 91.0-98.0), 4 for epilepsy (sensitivity: 98.8, specificity: 69.6, PPV: 62.0-100, NPV: 89.5-99.1), 4 for motor neuron disease (sensitivity: 78.9-93.0, specificity: 99.0-99.9, PPV: 38.0-90.0, NPV: 99), 2 for multiple sclerosis (sensitivity: 85-92.4, specificity: 55.9-92.6, PPV: 74.5-92.7, NPV: 70.8-91.9), 4 for Parkinson disease/parkinsonism (sensitivity: 18.7-100, specificity: 0-99.9, PPV: 38.6-81.0, NPV: 46.0), 3 for spinal cord injury (sensitivity: 0.9-90.6, specificity: 31.9-100, PPV: 27.3-100), and 3 for traumatic brain injury (sensitivity: 45.9-78.0 specificity: 97.8, PPV: 23.7-98.0, NPV: 99.2). No studies met eligibility criteria for cerebral palsy, dystonia, Huntington disease, hydrocephalus, muscular dystrophy, spina bifida, or Tourette syndrome. To ensure the accurate interpretation of population-based studies with use of administrative health data, the accuracy of case definitions for neurologic conditions needs to be taken into consideration.
            Article 0 comments Cited 62 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Self-reported medication adherence and treatment satisfaction in patients with epilepsy.

              Ikhlas Jarar, Adham Taha, Rana M Jamous … (2011)
              Reports about medication adherence and satisfaction in patients with epilepsy in Arab countries are lacking. The objective of this study was to assess medication adherence and its relationship with treatment satisfaction, number of antiepileptic drugs (AEDs) taken, and epilepsy control in a sample of Palestinian patients. This cross-sectional descriptive study was carried out at Al-Makhfya Governmental Outpatient Center in Nablus, Palestine, during the summer of 2010. A convenience sampling method was used to select patients over the study period. Medication adherence was measured using the eight-item Morisky Medication Adherence Scale (MMAS); treatment satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Epilepsy was arbitrarily defined as "well controlled" if the patient had had no seizures in the last 3 months and was defined as "poorly controlled" if he or she had had at least one seizure in the last 3 months. A convenience sample of 75 patients was studied. On the basis of the MMAS, 11 patients (14.7%) had a low rate, 37 (49.3%) had a medium rate, and 27 (36%) had a high rate of adherence. Adherence was positively and significantly correlated with age (P=0.02) and duration of illness (P=0.01). No significant difference in adherence was found between patients with well-controlled and those with poorly controlled epilepsy. Similarly, there was no significant difference in adherence between patients on monotherapy and those on polytherapy. Mean satisfaction with respect to effectiveness, side effects, convenience, and global satisfaction were 73.6±20.7, 82.4±29.8, 69.5±15.5, and 68.4±18.3, respectively. There were significant differences in mean values in the effectiveness (P<0.01) and convenience (P<0.01) domains, but not the side effect (P=0.1) and global satisfaction (P=0.08) domains among patients with different levels of adherence. Patients on monotherapy had significantly higher satisfaction in the effectiveness domain (P=0.04) than patients on polytherapy. Similarly, patients with well-controlled epilepsy scored significantly higher in the Effectiveness (P=0.01) and Global Satisfaction (P=0.01) domains than those with poorly controlled epilepsy. In our convenience sample, we found that adherence to and satisfaction with AEDs were moderate and were not associated with seizure control or number of AEDs. Copyright © 2011 Elsevier Inc. All rights reserved.
              Article 0 comments Cited 58 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Patient Prefer Adherence
                Journal ID (iso-abbrev): Patient Prefer Adherence
                Journal ID (publisher-id): Patient Preference and Adherence
                Title: Patient preference and adherence
                Publisher: Dove Medical Press
                ISSN (Electronic): 1177-889X
                Publication date Collection: 2016
                Publication date (Electronic): 31 October 2016
                Volume: 10
                Pages: 2197-2207
                Affiliations
                [1 ]Department of Neurology
                [2 ]Mongan Institute for Health Policy, Department of Medicine, Massachusetts General Hospital
                [3 ]Department of Health Care Policy, Harvard Medical School, Boston, MA
                [4 ]Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
                Author notes
                Correspondence: Lidia M V R Moura, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Wang 739D, Boston, MA 02114, USA, Tel +1 617 726 3311, Fax +1 617 726 9250, Email lidia.moura@ 123456mgh.harvard.edu
                Article
                Publisher ID: ppa-10-2197
                DOI: 10.2147/PPA.S119973
                PMC ID: 5096772
                PubMed ID: 27826186
                SO-VID: ae0728d0-2505-4b16-8603-2b4bace95125
                Copyright © © 2016 Moura et al. This work is published and licensed by Dove Medical Press Limited
                License:

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Medicine
                Keywords: epilepsy,antiepileptic drug side effects,medication adherence
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: epilepsy, antiepileptic drug side effects, medication adherence

                Comments

                Comment on this article