Nephrotic Syndrome and Focal Glomerular Sclerosis in Aging Man

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Abstract

Focal glomerular sclerosis (FGS) with the nephrotic syndrome is a disease of unknown etiology with its peak incidence in the third and fourth decades. Less than 2% of reported patients are older than 60 years of age, and to our knowledge no patients over 70 years of age have been described. The present report documents with renal biopsies the occurrence of FGS and the nephrotic syndrome in 4 patients with an average age of 70 years, 3 being septuagenarians. We suggest that FGS in these patients may represent a disease of senescence, and that FGS in younger patients may result from accelerated glomerulotubular senescence.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 02 December 2008

Volume: 20

Issue: 6

Pages: 307-315

Affiliations

Departments of Internal Medicine and Pathology, University of Virginia School of Medicine, Charlottesville, Va.

Article

Publisher ID: 181259 Other ID: Nephron 1978;20:307–315

DOI: 10.1159/000181259

PubMed ID: 662049

SO-VID: ae18a191-d613-4aef-b745-7050c5153d37

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 10 June 1977

Date accepted : 26 August 1977

Page count

Pages: 9

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