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      V3 Vasopressin Receptor and Corticotropic Phenotype in Pituitary and Nonpituitary Tumors

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          Pituitary corticotropic cells express a specific vasopressin receptor, called V1b or V3, through which vasopressin stimulates corticotropin secretion. We recently cloned a cDNA coding for this receptor and showed that it belongs to the G protein-coupled receptor family. V3 mRNA is readily detected by RT-PCR in normal human pituitaries and corticotropic pituitary adenomas but not in PRL or GH-secreting adenomas, thus demonstrating that, like POMC itself and the CRH receptor, V3 is a marker of the corticotropic phenotype. Nuclease protection experiments suggest that V3 is overexpressed in some corticotropic adenomas, and thus may play a role in tumor development by activating the phospholipase C-signalling pathway. In addition analysis of its expression in nonpituitary neuroendocrine tumors showed a striking association with carcinoids of the lung responsible for the ectopic ACTH syndrome.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          09 December 2008
          : 47
          : 4-6
          : 259-262
          aGroupe d’Etudes en Physiopathologie endocrinienne, Université René-Descartes, Institut Cochin de Génétique moléculaire, et bINSERM U36, College de France, Paris, France
          185473 Horm Res 1997;47:259–262
          © 1997 S. Karger AG, Basel

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          Pages: 4
          Recent Progress on the Molecular Aspects of Endocrine Tumors: Clinical Implications


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