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      Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).

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      Genomics

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          Abstract

          Human DCAMKL1, also known as KIAA0369, is a homologue of DCX (Xq22. 3), a gene associated with X-linked lissencephaly and subcortical band heterotopia. This suggests that DCAMKL1 may play a role in neuronal migration. The gene also shows similarity to Ca2+/calmodulin-dependent protein kinases. We have determined its genomic structure, regional mapping, and expression pattern in human tissues. DCAMKL1 consists of at least 18 exons ranging from 58 to 3359 bp in length. We have characterized the exon/intron borders, and primers were designed to amplify each individual exon for mutation analysis. DCAMKL1 was mapped to chromosome 13q13 by fluorescence in situ hybridization. Northern blot analysis showed DCAMKL1 to be predominantly expressed in human fetal brain as a major transcript of about 5.8 kb.

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          Author and article information

          Journal
          Genomics
          Genomics
          0888-7543
          0888-7543
          Mar 1 1999
          : 56
          : 2
          Affiliations
          [1 ] Department of Human Genetics, The University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637, USA.
          Article
          S0888-7543(98)95673-7
          10.1006/geno.1998.5673
          10051403
          ae32afc4-74e3-4e3c-9108-fdc1daacaa6e
          Copyright 1999 Academic Press.

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