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      CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment.

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          Abstract

          Multiple systems have been developed for grading the adverse effects (AEs) of cancer treatment. The National Cancer Institute Common Toxicity Criteria (CTC) system has substantially evolved since its inception in 1983. The most recent version, CTCAE v3.0 (Common Terminology Criteria for Adverse Events version 3.0) represents the first comprehensive, multimodality grading system for reporting the acute and late effects of cancer treatment. The new CTC requires changes in the application of AE criteria including new guidelines regarding late effects, surgical and pediatric effects, multimodality issues, and for reporting the duration of an effect. It builds on the strengths of previous systems, represents a considerable effort among hundreds of participants, and signifies an international collaboration and consensus of the oncology research community. This article updates recent progress in the evolution of adverse effects grading systems and reviews the development of CTCAE v3.0.

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          Author and article information

          Journal
          Semin Radiat Oncol
          Seminars in radiation oncology
          Elsevier BV
          1053-4296
          1053-4296
          Jul 2003
          : 13
          : 3
          Affiliations
          [1 ] H. Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL 33612, USA. Trotti@moffitt.usf.edu
          Article
          S1053-4296(03)00031-6
          10.1016/S1053-4296(03)00031-6
          12903007
          ae6934d6-c257-416f-97d1-b8954e525c6d
          History

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