Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.

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Abstract

Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease; however, the molecular basis underlying the sterile inflammatory response involved in the process of AAA remains unclear. We previously showed that the inflammasome, which regulates the caspase-1-dependent interleukin-1β production, mediates the sterile cardiovascular inflammatory responses. Therefore, we hypothesized that the inflammasome is a key mediator of initial inflammation in AAA formation.

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Author and article information

Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Jan 2015

Volume: 35

Issue: 1

Affiliations

[1 ] From the Division of Inflammation Resesarch, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan (F.U., K.S., H.K., K.T., A.K., T.K., M.T.); Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan (J.S., S.T.); Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan (K.Y.); Cardiovascular Research Institute, Kurume University, Kurume, Japan (H.A.); Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan (H.T.); and Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo, Japan (T.N.).

[2 ] From the Division of Inflammation Resesarch, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan (F.U., K.S., H.K., K.T., A.K., T.K., M.T.); Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan (J.S., S.T.); Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan (K.Y.); Cardiovascular Research Institute, Kurume University, Kurume, Japan (H.A.); Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan (H.T.); and Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo, Japan (T.N.). masafumi2@jichi.ac.jp.

Article

Publisher Item ID: ATVBAHA.114.303763

DOI: 10.1161/ATVBAHA.114.303763

PubMed ID: 25378412

SO-VID: ae6cfd40-8fcd-4ca6-91f2-14578e583e58

History

Keywords: cytokines,inflammation,macrophages,oxidative stress

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Keywords: cytokines, inflammation, macrophages, oxidative stress

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