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Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration.

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      Abstract

      A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and cardioprotective potential of this new bioactive system provides a valuable therapeutic platform for cardiac tissue repair and regeneration.

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      Affiliations
      [1 ] BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA. arghyapaul@ku.edu.
      [2 ] SRM University, Kattankulathur 603203, Tamilnadu, India.
      [3 ] Department of Pathology, University of Cincinnati, 231-Albert Sabin Way, Cincinnati 45267, OH, USA.
      Journal
      Nanoscale
      Nanoscale
      Royal Society of Chemistry (RSC)
      2040-3372
      2040-3364
      Apr 14 2016
      : 8
      : 14
      26876936
      10.1039/c5nr07806g
      4863075
      NIHMS781308

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