Changes in Growth Hormone-Binding Protein in Girls with Central Precocious Puberty Treated with a Depot Preparation of Luteinizing Hormone-Releasing Hormone Analogue

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Abstract

Growth hormone-binding protein (GHBP) was studied in 11 girls with true precocious puberty, aged 7.3 ± 0.2 years (mean ± SE), before and after the first 6 months of treatment with luteinizing hormone-releasing hormone analogue D-Trp<sup>6</sup>-LHRH. The <sup>125</sup>I-human GH was incubated with 150 µl of serum, bound and free GH were separated by gel filtration. The levels of GHBP increased significantly from 24.2 ± 1.3 to 28.1 ± 1.9% (p < 0.002, paired t test), more than expected for the normal age-dependent increase. The efficiency of LHRH-A therapy was confirmed by a decrease in growth rate and normalization of clinical and biological parameters. Our data agree with the hypothesis that the pubertal spurt is mediated by a sex-steroid-induced rise in GH concentration, and they suggest that the levels of GHBP may be related to the GH secretion and its variation with treatment.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1993

Publication date (Print): 1993

Publication date (Electronic): 03 December 2008

Volume: 39

Issue: 1-2

Pages: 42-46

Affiliations

Service d’Endocrinologie Pédiatrique, Hôpital St-Vincent-de-Paul, Paris, France

Article

Publisher ID: 182693 Other ID: Horm Res 1993;39:42–46

DOI: 10.1159/000182693

PubMed ID: 8406338

SO-VID: ae9e232f-420a-4ef0-a30d-d1787d340192

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 30 March 1992

Date accepted : 02 April 1993

Page count

Pages: 5

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