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      Open-chest epicardial ablation of ventricular tachycardia during a left ventricular assist device implantation: a case report

      case-report

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          Abstract

          Background

          Ventricular arrhythmias (VAs) are common after a left ventricular assist device (LVAD) implantation. Further, the majority of post-LVAD ventricular tachycardias (VTs) are secondary to a preexisting cardiomyopathy substrate. Intraoperative ablation of patients with recurrent preoperative VTs may reduce post-LVAD VTs.

          Case summary

          A 59-year-old female with advanced heart failure due to non-ischaemic cardiomyopathy (LV ejection fraction = 24%) and recurrent VTs was referred for an LVAD implantation as a bridge to a heart transplant (INTERMACS Profile-5A). The previous endocardial ablation failed due to an epicardial arrhythmogenic substrate. Therefore, open-chest epicardial mapping during the LVAD implantation was indicated and three target areas of the arrhythmogenic substrate were found, which were ablated by radiofrequency applications. To minimize the cardiopulmonary bypass time, cardiopulmonary bypass was initiated after ablation, and then, an LVAD was implanted. An additional 68 min was required for mapping and ablation. All procedures were performed without any complications, and the post-operative course was uneventful. Thereafter, no VT episodes were observed without any anti-arrhythmic drugs during a 15-month follow-up with LVAD support.

          Discussion

          Intraoperative epicardial mapping and ablation during an LVAD implantation can play an important role in the management of LVAD recipients with recurrent VAs.

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          Most cited references14

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          INTERMACS profiles of advanced heart failure: the current picture.

          The current classification of patients with New York Heart Association Class IV symptoms does not offer adequate description to allow optimal selection of patients for the current options of medical and pacing therapies, cardiac transplantation and mechanical circulatory support. Seven clinical profiles and an arrhythmia modifier were developed and implemented into the first year of data collection for the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). The INTERMACS Coordinators' Council provided ongoing feedback regarding the characterization of patients receiving implantable devices. The definition of 7 clinical profiles revealed that 80% of current devices are being used in the 2 profiles with the highest levels of clinical compromise. The INTERMACS Coordinators' Council helped to identify gaps in the characterization of hospitalized patients on temporary assist devices and of homebound patients with resting symptoms, which has led to revised definitions of Profile 3 and 4 and the addition of 2 new modifiers, for temporary circulatory support devices in the hospital, and for frequent rehospitalization of patients at home. Patients considered for mechanical circulatory support can now be classified using the 7 profiles plus 3 modifiers developed through INTERMACS. Further understanding these profiles and their impact on outcome should help to better select patients and therapies in the advanced stages of disease.
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            The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships

            The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory support (MCS) device to treat advanced heart failure. On January 1, 2018, the Intermacs Database became part of The Society of Thoracic Surgeons National Database, providing additional resources for quality assessment and improvement and scientific advancement.
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              Device Therapy and Arrhythmia Management in Left Ventricular Assist Device Recipients: A Scientific Statement From the American Heart Association

              Left ventricular assist devices (LVADs) are an increasingly used strategy for the management of patients with advanced heart failure with reduced ejection fraction. Although these devices effectively improve survival, atrial and ventricular arrhythmias are common, predispose these patients to additional risk, and complicate patient management. However, there is no consensus on best practices for the medical management of these arrhythmias or on the optimal timing for procedural interventions in patients with refractory arrhythmias. Although the vast majority of these patients have preexisting cardiovascular implantable electronic devices or cardiac resynchronization therapy, given the natural history of heart failure, it is common practice to maintain cardiovascular implantable electronic device detection and therapies after LVAD implantation. Available data, however, are conflicting on the efficacy of and optimal device programming after LVAD implantation. Therefore, the primary objective of this scientific statement is to review the available evidence and to provide guidance on the management of atrial and ventricular arrhythmias in this unique patient population, as well as procedural interventions and cardiovascular implantable electronic device and cardiac resynchronization therapy programming strategies, on the basis of a comprehensive literature review by electrophysiologists, heart failure cardiologists, cardiac surgeons, and cardiovascular nurse specialists with expertise in managing these patients. The structure and design of commercially available LVADs are briefly reviewed, as well as clinical indications for device implantation. The relevant physiological effects of long-term exposure to continuous-flow circulatory support are highlighted, as well as the mechanisms and clinical significance of arrhythmias in the setting of LVAD support.
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                Author and article information

                Contributors
                Role: Handling Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Journal
                Eur Heart J Case Rep
                Eur Heart J Case Rep
                ehjcr
                European Heart Journal: Case Reports
                Oxford University Press (US )
                2514-2119
                July 2023
                23 June 2023
                23 June 2023
                : 7
                : 7
                : ytad277
                Affiliations
                Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-Cho, Chuoh-Ku, Kobe 650-0017, Japan
                Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine Japan , 7-5-2 Kusunoki-Cho, Chuoh-Ku, Kobe 650-0017, Japan
                Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine Japan , 7-5-2 Kusunoki-Cho, Chuoh-Ku, Kobe 650-0017, Japan
                Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-Cho, Chuoh-Ku, Kobe 650-0017, Japan
                Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine , 7-5-2 Kusunoki-Cho, Chuoh-Ku, Kobe 650-0017, Japan
                Author notes
                Corresponding author. Tel: +81 78 382 5846, Email: kfuku@ 123456med.kobe-u.ac.jp

                Conflict of interest: None declared

                Author information
                https://orcid.org/0000-0003-4276-479X
                https://orcid.org/0000-0001-9736-7818
                Article
                ytad277
                10.1093/ehjcr/ytad277
                10325002
                ae9f4337-6a2e-47da-a8ef-3faf5a98f644
                © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                : 10 August 2022
                : 02 December 2022
                : 22 June 2023
                : 06 July 2023
                Page count
                Pages: 6
                Funding
                Funded by: Abbott JAPAN, DOI 10.13039/100009015;
                Funded by: Boston Scientific JAPAN, DOI 10.13039/100008497;
                Funded by: Medtronic JAPAN, DOI 10.13039/100019341;
                Funded by: Biotronik JAPAN;
                Categories
                Case Report
                Electrophysiology
                AcademicSubjects/MED00200
                Ehjcr/26
                Ehjcr/33
                Ehjcr/30
                Ehjcr/36
                Ehjcr/45

                left ventricular assist device,ventricular tachycardia,ablation,open-chest mapping,epicardial mapping,case report

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