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      A review of clinical photoacoustic imaging: Current and future trends

      review-article
      a , a , a , a , a , b , a , *
      Photoacoustics
      Elsevier
      AR-PAM, acoustic resolution-photoacoustic microscopy, DAQ, data acquisition, FOV, field-of-view, HbO2, oxy-hemoglobin, Hb, deoxy-hemoglobin, LED, light emitting diode, MAP, maximum amplitude projection, MEMS, microelectromechanical systems, MRI, magnetic resonance imaging, MSOT, multispectral optoacoustic tomography, OCT, optical coherence tomography, OR-PAM, optical resolution-photoacoustic microscopy, RSOM, raster-scanning optoacoustic mesoscopy, PA, photoacoustic, PAI, photoacoustic imaging, PAM, photoacoustic microscopy, PAT, photoacoustic tomography, SBH-PACT, single breath hold photoacoustic computed tomography system, sO2, saturation, US, ultrasound, Photoacoustic imaging, Optoacoustic tomography, Optoacoustic mesoscopy, Photoacoustic microscopy, Clinical applications

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Photoacoustic imaging (or optoacoustic imaging) is an upcoming biomedical imaging modality availing the benefits of optical resolution and acoustic depth of penetration. With its capacity to offer structural, functional, molecular and kinetic information making use of either endogenous contrast agents like hemoglobin, lipid, melanin and water or a variety of exogenous contrast agents or both, PAI has demonstrated promising potential in a wide range of preclinical and clinical applications. This review provides an overview of the rapidly expanding clinical applications of photoacoustic imaging including breast imaging, dermatologic imaging, vascular imaging, carotid artery imaging, musculoskeletal imaging, gastrointestinal imaging and adipose tissue imaging and the future directives utilizing different configurations of photoacoustic imaging. Particular emphasis is placed on investigations performed on human or human specimens.

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          Most cited references135

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          Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer

          New England Journal of Medicine, 347(16), 1233-1241
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            Contrast agents for molecular photoacoustic imaging.

            Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed laser light, it provides noninvasive images of absorbed optical energy density at depths of several centimeters with a resolution of ∼100 μm. This versatile and scalable imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced contrast agents. Understanding the relative merits of the vast range of contrast agents available, from small-molecule dyes to gold and carbon nanostructures to liposome encapsulations, is a considerable challenge. Here we critically review the physical, chemical and biochemical characteristics of the existing photoacoustic contrast agents, highlighting key applications and present challenges for molecular PAI.
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              A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle

              The vexing difficulty in delineating brain tumor margins represents a major obstacle toward better outcome of brain tumor patients. Current imaging methods are often limited by inadequate sensitivity, specificity, and spatial resolution. Here we show that a unique triple-modality Magnetic resonance imaging - Photoacoustic imaging – surface enhanced Raman scattering (SERS) nanoparticle (MPR) can accurately help delineate the margins of brain tumors in living mice both pre- and intra-operatively. The MPRs were detected by all three modalities with at least picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to specific MPR accumulation and retention by the tumors, allowing for non-invasive tumor delineation by all three modalities through the intact skull. Raman imaging allowed guidance of intra-operative tumor resection, and histological correlation validated that Raman imaging is accurately delineating brain tumor margins. This novel triple-modality nanoparticle approach holds promise to enable more accurate brain tumor imaging and resection.
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                Author and article information

                Contributors
                Journal
                Photoacoustics
                Photoacoustics
                Photoacoustics
                Elsevier
                2213-5979
                07 November 2019
                December 2019
                07 November 2019
                : 16
                : 100144
                Affiliations
                [a ]Laboratory of Bio-optical Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore
                [b ]Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
                Author notes
                Article
                S2213-5979(19)30067-9 100144
                10.1016/j.pacs.2019.100144
                6911900
                31871888
                aea4d15c-857c-4e0d-9b44-ee0f7317a3bd
                © 2019 The Authors

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                : 3 May 2019
                : 5 July 2019
                : 21 August 2019
                Categories
                Review Article

                ar-pam, acoustic resolution-photoacoustic microscopy,daq, data acquisition,fov, field-of-view,hbo2, oxy-hemoglobin,hb, deoxy-hemoglobin,led, light emitting diode,map, maximum amplitude projection,mems, microelectromechanical systems,mri, magnetic resonance imaging,msot, multispectral optoacoustic tomography,oct, optical coherence tomography,or-pam, optical resolution-photoacoustic microscopy,rsom, raster-scanning optoacoustic mesoscopy,pa, photoacoustic,pai, photoacoustic imaging,pam, photoacoustic microscopy,pat, photoacoustic tomography,sbh-pact, single breath hold photoacoustic computed tomography system,so2, saturation,us, ultrasound,photoacoustic imaging,optoacoustic tomography,optoacoustic mesoscopy,photoacoustic microscopy,clinical applications

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