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Neuropeptides, food intake and body weight regulation: a hypothalamic focus
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Abstract
Energy homeostasis is controlled by a complex neuroendocrine system consisting of
peripheral signals like leptin and central signals, in particular, neuropeptides.
Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic
(NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling
system. Starvation as well as overfeeding lead to changes in expression levels of
these neuropeptides, which act downstream of leptin, resulting in a physiological
response. In this review the role of several anorexigenic and orexigenic (hypothalamic)
neuropeptides on food intake and body weight regulation is summarized.