Patient-specific dosimetry using pretherapy [¹²⁴I]m-iodobenzylguanidine ([¹²⁴I]mIBG) dynamic PET/CT imaging before [¹³¹I]mIBG targeted radionuclide therapy for neuroblastoma.

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Abstract

Iodine-131-m-iodobenzylguanidine ([(131)I]mIBG)-targeted radionuclide therapy (TRT) is a standard treatment for recurrent or refractory neuroblastoma with response rates of 30-40 %. The aim of this study is to demonstrate patient-specific dosimetry using quantitative [(124)I]mIBG positron emission tomography/X-ray computed tomography (PET/CT) imaging with a GEometry ANd Tracking 4 (Geant4)-based Monte Carlo method for better treatment planning.

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Journal

Journal ID (iso-abbrev): Mol Imaging Biol

Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

ISSN (Electronic): 1860-2002

ISSN (Print): 1536-1632

Publication date (Electronic): Apr 2015

Volume: 17

Issue: 2

Affiliations

[1 ] Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, 94143-0946, USA, Shih-ying.Huang@ucsf.edu.

Article

Mid ID: NIHMS622874

DOI: 10.1007/s11307-014-0783-7

PMC ID: 4336853

PubMed ID: 25145966

SO-VID: aed6ae46-e2db-4b50-a208-601f97deb484

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