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      Liver histopathology of the fish brachydanio rerio hamilton-buchman after acute exposure to sublethal levels of the organophosphate dimethoate 500

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          Abstract

          Among the new substances that were synthesised by the chemical industiy during the last decades, with the aim to improve human prosperity, some cause negative effects on non target organisms like fish. Among the pesticides, the organophosphates (OP) are widely used in cattle management, agriculture and aquaculture activities. Brachydanio rerio Hamilton-Buchman, 1822 is used world-wide in fish-tests for the establishment of the lethal levels of pesticides. Nevertheless, these fish show morphological changes in their hepatocytes when exposed experimentally for 24 hours to the sublethal dose of 0.025 µl/l of the OP Dimethoate 500, in acute tests. Right hours after exposure, a high density of cells with cytoplasmic granulation is seen as well as focal necrosis. The main changes that occurred in the first 24 hours of exposure were the loss of the typical polygonal cell shape and of detectable cell limits, lateral migration of nuclei, nuclear size and shape, condensation of chromatin and pycnosis, increased cytoplasmic granulation followed by vacuolisation. After 48 hours in clean water, 72 hours from contamination, besides significant morphological changes and necrosis, focal regeneration of the hepatocytes, canaliculi, ducts and sinusoids were seen. Even having been exposed to the half of the dose considered as safe according to the general pesticide allowance rules, significant changes of the liver tissue were observed.

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          Most cited references30

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          Toxicology of Insecticides

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            The Toxicity of Organic Phosphorus Insecticides to Different Species of Warmwater Fishes

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              Sex-specific reaction of liver ultrastructure in zebra fish (Brachydanio rerio) after prolonged sublethal exposure to 4-nitrophenol

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                Author and article information

                Journal
                rbzool
                Revista Brasileira de Zoologia
                Rev. Bras. Zool.
                Sociedade Brasileira de Zoologia (Curitiba, PR, Brazil )
                0101-8175
                1998
                : 15
                : 2
                : 441-450
                Affiliations
                [01] São Paulo São Paulo orgnameFaculdade Adventista de Ciências orgdiv1Instituto Adventista de Ensino Brazil
                Article
                S0101-81751998000200014 S0101-8175(98)01500214
                10.1590/S0101-81751998000200014
                aee4ebcd-f606-4ffd-835b-3eca18e93067

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 10 June 1998
                : 17 April 1997
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 32, Pages: 10
                Product

                SciELO Brazil


                Dimethoate,sublethal contamination,organophosphates,liver,fish,histopathology

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