Dear Editor
Telemedicine (TM) can be defined as the exchange of medical data through technology
applications and devices,[1] opening door to different ways in diagnosing and in taking
care at different levels and ages.[2
3]
This communication aimed to draw attention on the feasibility of technology applications
in preliminary diagnosis.
A 30-year-old Caucasian woman contacted our department by telephone to explain her
signs and symptoms. She reported that 3 days before she had visited the emergency
department because of the appearance of lip swelling. This sign was attributed to
a food allergy, and she was discharged with a 5-day therapy with prednisone and antihistamine.
Also, she reported that she returned to the same institution a day later with vesicular
eruptions affecting her upper lip and genital mucosa, so orogenital Herpes simplex
virus 2 infection was suspected and she was prescribed valacyclovir 2000mg/day, without
any improvement.
On the basis of this report, we asked her to send pictures of oral and other manifestations
by WhatsApp Messenger chat room. Telephone agreement in sending pictures was obtained,
and the patient wrote in a further text message her consent in sending images for
the smartphone triage. Images were self-portrait taken by patient with the smartphone
camera (8 MP)[4] [Figures 1 and 2].
Figure 1
Oral painful ulcers 3 days after the first administration of fluconazole
Figure 2
Lip swelling 1 day after the first administration of fluconazole
Thanks to telephonic indications and pictures sent, we were able to frame the condition
and set a multidisciplinary team for the visit: oral pathologist, dermatologist, and
gynecologist.
She came to our attention and she signed a written consent to be visited and to undergo
blood tests, and on the same occasion, the patient signed a specific form giving us
the written consent for storing her photographs shared via WhatsApp Messenger. All
sensitive personal information of the patient, including the photographs sent, was
recorded and archived in the hospital database.
Signs observed were oral and genital painful ulcers affecting swallowing, sitting
and urinating, myalgia, and temperature <38.0°C. No skin rashes were observed.
Our team carried out pathological and medical evaluations, which indicated a previous
vaginal candidiasis treated with 200mg/day oral fluconazole for 2 days, prescribed
by her gynecologist. To exclude previous diagnoses, serological test for immunoglobulin
(Ig)G and IgM anti-HSV was performed, and it revealed only IgG positivity.
After clinical evaluation and serological test, signs were discussed and all three
specialists agreed on the diagnosis of incomplete Stevens Johnson syndrome. She, therefore,
received deflazacort 30mg, and complete remission was observed in 14 days, without
complication.
The diagnosis was actually carried out based on a clinical visit; however, the smartphone
triage allowed recruiting a suitable team that was able to effectively assess signs
and symptoms. Moreover it was possible, thanks to the images received, to collect
data of the patient living far, and in this way, she could avoid further wasted visits.
On the basis of these findings, it might be advisable to discuss the feasibility to
improve and increase this first way of communication between patient and physicians
to frame diseases early and perform a well-timed diagnosis.
TM incorporates technologies and activities, offering new ways to deliver medical
care; apps are downloadable on mobile phones, and they could represent a valuable
help in early placement of signs[5] and for saving costs and time for patients and
healthcare facilities.
Furthermore, it might be taken into account the great opportunity to avail of TM in
weak countries or in rural areas where healthcare facilities and healthcare financing
are poor. Literature reports valuable works about the effectiveness of TM in early
diagnosis of oral alterations[6] and skin diseases.[7] It is proven that the feasibility
to use images sent by smartphone in performing first diagnoses or planning referral
results in saving time and costs, and preserving the health of patients who are not
able to easily reach healthcare facilities.[6
8,9]
Advantages of this helpful method are surely performing a triage and the feasibility
to address patients to most suited specialist avoiding time-consuming visits, unnecessary
instrumental examinations, and delayed diagnoses. However, some criticism has to be
taken into account, especially regarding privacy and treatment of sensitive data.
In this perspective, it is advisable to inform patients about the storing of data
and it would be even more desirable if healthcare adequate their privacy systems of
data collected performing telemedicine. Moreover, instructing patients to send images
of lesions avoiding, to the extent practicable, personal details, which can make them
recognizable in photographs could be helpful in protecting privacy. Another critical
point is represented by the quality of sent images, even if performances of smartphone
cameras are notably improved in the last years.
By well considering the routine medical practice and clinical evidences obtained,
we think it would be possible to improve several aspects of health management in terms
of early diagnosis. Of course, it might be useful to enhance and to better set the
privacy context to protect data shared by apps or patient’s smartphones.
DECLARATION OF PATIENT CONSENT
The authors certify that they have obtained all appropriate patient consent forms.
In the form the patient(s) has/have given his/her/their consent for his/her/their
images and other clinical information to be reported in the journal. The patients
understand that their names and initials will not be published and due efforts will
be made to conceal their identity, but anonymity cannot be guaranteed.
FINANCIAL SUPPORT AND SPONSORSHIP
Nil.
CONFLICTS OF INTEREST
There are no conflicts of interest.
ETHICAL CONSIDERATIONS
All procedures performed in studies involving human participants were in accordance
with the ethical standards of the institutional research committee (University of
Verona, Italy) and with the 1964 Helsinki declaration and its later amendments or
comparable ethical standards.
AUTHOR CONTRIBUTIONS
PG: Substantial contributions to the conception or design of the work; NR: the acquisition,
analysis, or interpretation of data for the work; CG: Drafting the work or revising
it critically for important intellectual content; ZF: Final approval of the version
to be published; AM :Agreement to be accountable for all aspects of the work in ensuring
that questions related to the accuracy or integrity of any part of the work are appropriately
investigated and resolved.