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      Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days

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          Abstract

          More than half a century of skeletal muscle research is continuing at Padua University (Italy) under the auspices of the Interdepartmental Research Centre of Myology (CIR-Myo), the European Journal of Translational Myology (EJTM) and recently also with the support of the A&CM-C Foundation for Translational Myology, Padova, Italy. The Volume 30(1), 2020 of the EJTM opens with the collection of abstracts for the conference “2020 Padua Muscle Days: Mobility Medicine 30 years of Translational Research”. This is an international conference that will be held between March 18-21, 2020 in Euganei Hills and Padova in Italy. The abstracts are excellent examples of translational research and of the multidimensional approaches that are needed to classify and manage (in both the acute and chronic phases) diseases of Mobility that span from neurologic, metabolic and traumatic syndromes to the biological process of aging. One of the typical aim of Physical Medicine and Rehabilitation is indeed to reduce pain and increase mobility enough to enable impaired persons to walk freely, garden, and drive again. The excellent contents of this Collection of Abstracts reflect the high scientific caliber of researchers and clinicians who are eager to present their results at the PaduaMuscleDays. A series of EJTM Communications will also add to this preliminary evidence.

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          Most cited references 228

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          STIM1, an essential and conserved component of store-operated Ca2+ channel function

          Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference (RNAi)-based screen to identify genes that alter thapsigargin (TG)-dependent Ca2+ entry, we discovered a required and conserved role of Stim in SOC influx. RNAi-mediated knockdown of Stim in Drosophila S2 cells significantly reduced TG-dependent Ca2+ entry. Patch-clamp recording revealed nearly complete suppression of the Drosophila Ca2+ release-activated Ca2+ (CRAC) current that has biophysical characteristics similar to CRAC current in human T cells. Similarly, knockdown of the human homologue STIM1 significantly reduced CRAC channel activity in Jurkat T cells. RNAi-mediated knockdown of STIM1 inhibited TG- or agonist-dependent Ca2+ entry in HEK293 or SH-SY5Y cells. Conversely, overexpression of STIM1 in HEK293 cells modestly enhanced TG-induced Ca2+ entry. We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
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            CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.

            Store-operated Ca2+ entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels following Ca2+ release from intracellular stores. We performed a genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins that inhibit store-operated Ca2+ influx. A secondary patch-clamp screen identified CRACM1 and CRACM2 (CRAC modulators 1 and 2) as modulators of Drosophila CRAC currents. We characterized the human ortholog of CRACM1, a plasma membrane-resident protein encoded by gene FLJ14466. Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery.
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              Publication recommendations for electrodermal measurements.

              This committee was appointed by the SPR Board to provide recommendations for publishing data on electrodermal activity (EDA). They are intended to be a stand-alone source for newcomers and experienced users. A short outline of principles for electrodermal measurement is given, and recommendations from an earlier report (Fowles et al., ) are incorporated. Three fundamental techniques of EDA recording are described: (1) endosomatic recording without the application of an external current, (2) exosomatic recording with direct current (the most widely applied methodology), and (3) exosomatic recording with alternating current-to date infrequently used but a promising future methodology. In addition to EDA recording in laboratories, ambulatory recording has become an emerging technique. Specific problems that come with this recording of EDA in the field are discussed, as are those emerging from recording EDA within a magnetic field (e.g., fMRI). Recommendations for the details that should be mentioned in publications of EDA methods and results are provided. Copyright © 2012 Society for Psychophysiological Research.
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                Author and article information

                Journal
                Eur J Transl Myol
                EJTM
                European Journal of Translational Myology
                PAGEPress Publications, Pavia, Italy
                2037-7452
                2037-7460
                01 April 2020
                07 April 2020
                : 30
                : 1
                Affiliations
                [(1) ] Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova , Italy
                [(2) ] A&C M-C Foundation for Translational Myology , Padova, Italy
                University of Florida, Institute on Aging, College of Medicine , Vice-Chair of Research and Professor Department of Aging and Geriatric Research. Chief, Division of Biology of Aging, Gainesville, FL, USA
                [(1) ] Center for Cognitive Aging and Memory, Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida , Gainesville, USA
                [(2) ] Department of Neuroscience, Gainesville, University of Florida , USA
                [(3) ] Institute on Aging, Department of Aging and Geriatric Research , University of Florida , Gainesville, FL, USA
                Department of Oncology and Molecular Medicine, Istituto Superiore di Sanita (ISS) , Rome Italy
                [(1) ] Graduate School of Arts and Sciences, University of Tokyo , Tokyo, Japan
                [(2) ] Department of Neuromuscular Research, National Institute of Neuroscience , National Center of Neurology and Psychiatry , Tokyo, Japan
                [(3) ] Kobayashi Institute of Physical Research , Tokyo, Japan
                [(4) ] Hitachi Aloka Medical Ltd. , Tokyo, Japan
                [(5) ] Present address: Tokyo University of Science , Tokyo. Japan
                [(1) ] Microbial Chemistry Research Foundation, Institute of Microbial Chemistry , Tokyo, Japan
                [(2) ] Laboratory of Muscle Biology, Tokyo Women’s Christian University , Tokyo, Japan
                Osato Research Institute , Gifu, Japan
                [(1) ] Oroboros Instruments , Innsbruck, Austria
                [(2) ] D Swarovski Research Lab, Department of Visceral, Transplant Thoracic Surgery , Med Univ Innsbruck , Austria
                Department of Biomedical Sciences, University of Padova , Italy
                [(1) ] Department of Physical Therapy, and Department of Physiology & Functional Genomics, University of Florida , USA
                [(2) ] Department of Applied Physiology & Kinesiology, University of Florida , USA
                [(3) ] Rehabilitation Sciences Doctoral Program, University of Florida , USA
                [(4) ] Meakins Christie Laboratories, Research Institute of the McGill University Health Centre; McGill University , Montreal, Canada
                [(1) ] Mitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia , Philadelphia, USA
                [(2) ] Department of Pediatrics, University of Pennsylvania Perelman School of Medicine , Philadelphia, USA
                [(1) ] Department of Biomedical Sciences, University of Padova , Italy
                [(2) ] CIR-Myo Myology Centre, University of Padova , Italy
                [(3) ] Department Surgery, Oncology, and Gastroenterology, University of Padova , Italy
                Histology and Embryology Section, Dept. AHFOS, Sapienza University of Rome , Italy
                [(1) ] Department of Biology, University of Padova , Italy
                [(2) ] Department of Biomedical Science, University of Padova , Italy
                [(3) ] CNR Neurosciene Institute , Padova, Italy
                [(4) ] CRIBI Biotechnology Center, University of Padova , Italy
                [(5) ] Venetian Institute of Molecular Medicine , Padova, Italy
                [(6) ] CIR-Myo Myology Center, University of Padova , Italy
                Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida , Gainesville, FL USA
                [(1) ] Faculty of Sport Sciences and Physical Education , University of Coimbra
                [(2) ] IBILI – Faculty of Medicine, University of Coimbra
                [(3) ] Orthopaedic Department of CHUC , Coimbra, Portugal
                Department of Neurosciences, Padua University , Italy
                Department of Anatomy, University of Bern , Bern, Switzerland
                [(1) ] Department of Otorhinolaryngology, Jena University Hospital , Jena, Germany
                [(2) ] Institute of Systematic Zoology and Evolutionary Biology with Phyletic Museum , Friedrich-Schiller-University Jena , Jena, Germany
                [(3) ] Computer Vision Group, Friedrich-Schiller-University Jena
                [(4) ] Medical University Vienna , Center for Medical Physics and Biomedical Engineering, General Hospital Vienna , Vienna, Austria
                [(1) ] Center for Cognitive Aging and Memory, Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida , USA
                [(2) ] Department of Neuroscience, University of Florida , USA –
                Institute for Biomedical and Neural Engineering, Reykjavík University , Reykjavík, Iceland and Landspitali, Iceland
                [(1) ] Institute for Sport and Health, University College Dublin , Ireland
                [(2) ] CIR-Myo & Dept. of Biomedical Sciences, Padua University , Italy.
                [(1) ] D Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Med Univ Innsbruck , Austria
                [(2) ] Oroboros Instruments , Innsbruck, Austria
                Media System Lab S.r.l. , Macherio (MB), Italy
                Myology Institute, University of Florida , Gainesville, FL USA
                Institute of Myology , Myology Research Center, UMRS 974 UPMC - INSERM - AIM, GH Pitie Salpetrière, Paris, France
                [(1) ] Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova , Padova, Italy
                [(2) ] Vollum Institute, Oregon Health and Science University , Portland, Oregon
                [(3) ] Department of Physiology & Pharmacology, Oregon Health and Science University , Portland, Oregon
                [(4) ] Medicinal Chemistry Core, Oregon Health & Science University , Portland, Oregon
                [(5) ] Department of Biology, University of Padova , Padova, Italy
                [(6) ] Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna, Italy
                [(7) ] CNR Institute of Molecular Genetics and Laboratory of Musculoskeletal Cell Biology, Istituto Ortopedico Rizzoli-IRCCS , Bologna, Italy
                [(1) ] IRCCS S.Camillo Hospital , Venice, Italy
                [(2) ] Laboratory of Cellular Biochemistry and Molecular Biology, CRIBENS, Catholic University of the Sacred Heart , pz Buonarroti 30, Milan 20145, Italy
                [(3) ] Psychology Department, Catholic University of the Sacred Heart , Largo Gemelli 1, Milan 20123, Italy
                [(1) ] CAST, University G. d'Annunzio of Chieti
                [(2) ] DMSI, University G. d'Annunzio of Chieti
                [(3) ] DNICS, University G. d'Annunzio of Chieti , Italy
                [(1) ] Anatomy Dept., SIU School of Medicine , Carbondale, Illinois, USA
                [(2) ] Dept of Biochemistry, SIU School of Medicine , Carbondale, Illinoi, USA
                [(3) ] Bioinformatics Core, Purdue University , West Lafayette, Indiana, USA
                [(4) ] Medicinal Chemistry and Molecular Pharmacology, Purdue University , West Lafayette, Indiana, USA
                CAST & DNISC, University G. d'Annunzio of Chieti , Italy
                Dept. of Radiology, Muscle Imaging and Modeling Lab, University of California at San Diego, School of Medicine , San Diego, CA, USA
                Department of Physics, San Diego State University , San Diego, CA, USA
                [(1) ] Department of Biomedical Sciences, University of Padova , Italy
                [(2) ] CIR-Myo Myology Centre, University of Padova , Italy
                [(3) ] Department of Medicine, Surgery and Health Sciences, University of Trieste , Trieste, Italy
                [(4) ] Department Surgery, Oncology, and Gastroenterology, University of Padova , Italy
                [(5) ] Science and Research Centre Koper , Koper, Slovenia
                [(1) ] Institute of Physiology, Department of Biomedical Sciences , University of Padua , Italy
                [(2) ] Sports Medical Research Group, Department of Orthopaedics, Balgrist University Hospital, University of Zurich , Switzerland
                Department of Neuroscience, Institute of Human Anatomy, University of Padova , Italy
                [(1) ] CIR-Myo, Myology Centre, University of Padova , Italy
                [(2) ] Department of Biomedical Sciences, University of Padova , Italy
                [(3) ] A&CM-C Foundation for Translational Myology, Padova, Italy
                Physiko und Rheumatherapie, Institute for Physical Medicine and Rehabilitation , St. Pölten, Austria; Ludwig Boltzmann Institute for Rehabilitation Research , St. Pölten, Austria
                Ludwig Boltzmann Institute for Rehabilitation Research , St. Poelten, Austria
                Faculty of Physical Education and Sports, Comenius University , Bratislava, Slovakia
                [(1) ] University of Primorska , Faculty of Health Sciences, Izola, Slovenia
                [(2) ] S2P, Science to Practice, Laboratory for Motor Control and Motor Behaviour , Ljubljana, Slovenia
                CAST & DMSI, University G. d'Annunzio of Chieti , Italy
                Sapienza University of Rome , Italy
                [(1) ] Department of Surgery, Oncology and Gastroenterology, University of Padova , Italy
                [(2) ] Department of Biomedical Sciences, University of Padova , Italy
                [(3) ] Venetian Institute of Molecular Medicine , Padova, Italy
                [(1) ] Department of Neuroscience, Section of Human Anatomy, University of Padova , Italy
                [(2) ] CIR-Myo, Interdepartmental Research Center of Myology, University of Padova , Italy
                [(3) ] Department of Biomedical Sciences (DSB), University of Padova , Italy
                [(4) ] A&CM-C Foundation for Translational Myology , Padova, Italy
                [(5) ] Department of Neuroscience, Institute of Plastic Surgery, University of Padova , Italy
                [(6) ] Department of Surgery, Oncology, and Gastroenterology, University of Padova , Italy
                [(1) ] Department of Biological and Medical Sciences, Faculty of Physical Education and Sport, Comenius University (Bratislava , Slovakia
                [(2) ] Faculty of Medicine, Slovak Medical University (Bratislava, Slovakia)
                [(3) ] Department of Urology, University Hospital in Bratislava (Bratislava, Slovakia)
                [(4) ] Biomedical Centre, Slovak Academy of Sciences (Bratislava, Slovakia)
                [(5) ] Faculty of Medicine, Comenius University (Bratislava, Slovakia)
                [(6) ] Department of Physical Performance, Norwegian School of Sport Sciences (Oslo, Norway)
                [(1) ] CAST - University G. d'Annunzio of Chieti , Italy
                [(2) ] CETAPS - University of Rouen Normandy , France
                [(3) ] DMDM, University of Siena & Azienda Ospedaliera Universitaria Senese , Italy
                [(4) ] DNICS, University G. d'Annunzio of Chieti , Italy
                [(5) ] Ludwig Boltzmann Institute for Physical Rehabilitation , Vienna, Austria
                [(6) ] DMSI, University G. d'Annunzio of Chieti , Italy
                [(1) ] Center for Implantable Technology and Sensors, ITIS d. o. o. Ljubljana, Ljubljana , Republic of Slovenia
                [(2) ] Division of Gynaecology and Obstetrics, Šlajmerjeva 3 and Zaloška 7, Ljubljana , Republic of Slovenia
                [(3) ] Institute of Pathophysiology , Faculty of Medicine, University of Ljubljana , Ljubljana, Republic of Slovenia
                [(1) ] Servizio Provinciale di Medicina dello Sport Ospedale Brunico-Bruneck e San Candido-Innichen , Italy
                [(2) ] Department of Medicine, University of Perugia , Italy
                [(3) ] Laboratory of Sport Physiology, San Candido-Innichen , Italy
                [(4) ] Erbil Polytechnic University , Kurdistan – Iraq
                [(5) ] IIM-Interuniversity Institute of Myology and A&CM-C Foundation for Translational Myology , Padova; Italy
                [(6) ] Università Politecnica delle Marche , Italy
                [(1) ] Department of Medical Physics and Biomedical Engineering, Medical University of Vienna , Austria
                [(2) ] Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova , Italy
                [(1) ] Institute for Biomedical and Neural Engineering , Reykjavík University , Reykjavík, Iceland
                [(2) ] Department of Advanced Biomedical Sciences, University Hospital of Naples ‘Federico II’ , Naples, Italy
                [(3) ] CIR-Myo and Department of Biomedical Sciences, University of Padova , Italy
                [(4) ] A&CM Carraro Foundation for Translationa Myology , Padova, Italy
                [(5) ] IRCCS Fondazione Ospedale San Camillo , Venice, Italy
                [(6) ] Department of Rehabilitation, Landspítali , Reykjavík, Iceland
                [(1) ] Institute for Biomedical and Neural Engineering , Reykjavík University , Reykjavík, Iceland
                [(2) ] 2 School of Life and Health Sciences, Aston University , Birmingham, UK
                [(3) ] Univ Rennes , LTSI, F-35000, Rennes, France
                [(4) ] Department of Anatomy, University of Iceland , Reykjavík, Iceland
                [(5) ] Department of Science, Landspitali , Reykjavik, Iceland
                [(1) ] CAST - University G. d'Annunzio of Chieti , Italy
                [(2) ] DMSI, University G. d'Annunzio of Chieti , Italy
                [(3) ] DNICS, University G. d'Annunzio of Chieti , Italy
                [(4) ] Dept. of Biomolecular Sciences, University of Urbino Carlo Bo , Italy
                [(5) ] Dept. of Biomedical Sciences, University of Padova , Italy
                [(1) ] Health Technology Center, Reykjvik University and Landspitali University Hospital , Reykjavik, Iceland
                [(2) ] Rehabilitation Department at Grensas, Landspitali University Hospital , Reykjavik, Iceland
                [(1) ] Department of Neuroscience, Institute of Human Anatomy, University of Padova , Italy
                [(1) ] Department of Biomedical Sciences, University of Padova , Italy
                [(2) ] Centre for Mechanics of Biological Materials, University of Padova , Italy
                [(3) ]Department of Industrial Engineering, University of Padova , Italy
                [(1) ] IRCCS S. Camillo Hospital , Venice, Italy
                [(2) ] Laboratory of Cellular Biochemistry and Molecular Biology, CRIBENS, Catholic University of the Sacred Heart , Milan, Italy
                [(3) ] Psychology Department, Catholic University of the Sacred Heart , Milan Italy
                [(1) ] Department of Genomic Medicine, Hospital National Center for Global Health and Medicine , Tokyo, Japan
                [(2) ] Medical Genomics Center, National Center for Global Health and Medicine , Tokyo, Japan
                [(3) ] Institute of Medical Genetics , Tokyo Women’s Medical University , Tokyo, Japan
                [(4) ] Laboratory of Virology, Institute of Microbial Chemistry , Tokyo, Japan
                Department of Oncology and Molecular Medicine, Istituto Superiore di Sanita (ISS) , Rome Italy
                [(1) ]Department of Neuroscience, Institute of Human Anatomy, University of Padova , Padova, Italy
                [(2) ] Department of Surgery, Oncology and Gastroenterology DiSCOG, Orthopedic Clinic, University of Padova , Padova, Italy
                [(3) ] Physical and Rehabilitation Medicine, University of Rome “Tor Vergata” , Italy
                [(1) ] A&CM-C Foundation for Translational Myology , Padova, Italy
                [(2) ] CIR-Myo, Interdepartmental Research Center of Myology, University of Padova , Italy
                [(3) ] Department of Biomedical Sciences (DSB), University of Padova , Italy
                [(4) ] Department of Neuroscience, Institute of Human Anatomy, University of Padova , Italy
                [(1) ] Oroboros Instruments , Innsbruck, Austria
                [(2) ] Dept Physiological Sciences, Univ Barcelona Bellvitge Biomedical Research Inst (IDIBELL) , Spain
                [(3) ] DMEM, INRA, Univ Montpellier , France
                [(4) ] German Inst Human Nutrition Potsdam-Rehbruecke , Potsdam, Germany
                [(5) ] Translational Research Inst Metabolism Diabetes, Florida Hospital , Orlando, FL, USA
                [(6) ] Inst Clinical Diabetology, German Diabetes Center, Leibniz Center Diabetes Research Heinrich-Heine Univ Düsseldorf
                [(7) ] German Center Diabetes Research , Munich, Neuherberg; Germany
                [(8) ] Fac Saint-Jean, Univ Alberta , Canada
                [(9) ] Lab Chemical Biology, National Inst Chemical Physics Biophysics , Tallinn, Estonia
                [(10) ] Lab Bioénergétique Fondamentale Appliquée, Univ Grenoble Alpes , INSERM, Grenoble, France
                [(11) ] Dept Neurological Movement Sciences, Univ Verona , Italy
                [(12) ] Dept Molecular Cellular Pathology Therapy, Inst Biomedicina de Valencia , Spain
                [(13) ] Biomedical Research Center, Univ Granada , Spain
                [(14) ] Metabolism Obesity Lab, Vall d’Hebron Research Inst , Barcelona, Spain
                [(15) ] Human Animal Physiology, Wageningen Univ , The Netherlands
                [(16) ] Dept Physiology, Development Neuroscience, Univ Cambridge , UK
                [(17) ] Dept Radiology, Univ Washington , South Lake Union, USA
                [(18) ] Dept Human Movement Sciences, Fac Behavioural Movement Sciences, Vrije Univ Amsterdam , The Netherlands
                [(19) ] Rehabilitation Inst Chicago, Feinberg School Medicine , Northwestern Univ, USA
                [(20) ] Dept Biomedical Sciences, Center Healthy Aging, Fac Health Sciences , Denmark
                [(21) ] The Novo Nordisk Center Basic Metabolic Research, Section Integrative Physiology; Univ Copenhagen , Denmark
                [(22) ] D Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Med Univ Innsbruck , Austria
                [(1) ]. CIR-Myo, Interdepartmental Research Center of Myology, University of Padova , Italy
                [(2) ] Department of Biomedical Sciences (DSB), University of Padova , Italy
                [(3) ] A&CM-C Foundation for Translational Myology , Padova, Italy
                [(4) ] Ludwig Boltzmann Institute of Rehabilitation Research , St Pölten, Austria
                [(5) ] Institute of Physical Medicine and Rehabilitation, Prim. Dr. H Kern GmbH , Amstetten, Austria
                [(6) ] Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova , Italy
                [(7) ] Department of Neuroscience, Institute of Human Anatomy, University of Padova , Italy
                [(1) ] CIR-Myo Myology Centre, University of Padova , Italy
                [(2) ] Department of Biomedical Sciences, University of Padova , Italy
                [(3) ] A&CM-C Foundation for Translational Myology , Padova,Italy
                [(4) ] Videomaker , Padova, Italy
                [(5) ] Deparment of Neuroscience, Section of Ortopedic Rehabilitation, Padova General Hospital, Uniiversity of Padova , Italy
                [(6) ] Highly Specialized Rehabilitation Hospital , Motta di Livenza, Treviso, Italy
                [(1) ] PhD Program in Health Promotion and Cognitive Sciences, University of Palermo , Palermo, Italy
                [(2) ] Department of Psychology, Educational Science and Human Movement, University of Palermo , Palermo, Italy
                [(3) ] Center for Physical Medicine and Rehabilitation “Vitality” , Vita, Trapani, Italy
                [(4) ] Posturalab Italia Research Institute , Palermo, Italy
                [(1) ] Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF)
                [(2) ] Department of Psychological, Pedagogical, Physical Exercise and Training Sciences, University of Palermo , Italy
                [(1) ] Department of Psychology, Educational Science and Human Movement
                [(2) ] Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF)
                [(3) ] Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D.), University of Palermo , Palermo, Italy
                Author notes
                Department of Biomedical Sciences, University of Padova, Italy. ORCID iD: 0000-0002-0924-4998 ugo.carraro@ 123456unipd.it

                Conflict of Interest

                The author declare to have none conflicts of interests.

                Article
                10.4081/ejtm.2019.8826
                7254447

                This article is distributed under the terms of the Creative Commons Attribution Noncommercial License ( by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

                Page count
                Figures: 1, Tables: 0, Equations: 0, References: 307, Pages: 45
                Categories
                Article

                2020 padua muscle days, translational research, mobility medicine, biology of aging, ”anti-aging”, strategies, epicatechins, clinical outcomes, fermented papaya product, cognitive aging, brain aging, fpp®, immunage, cancer prevention, rejuvenation, dietary phosphorus overload, mdx mouse, calcium, vitamin c, neuromuscular diseases, natural products, neuromuscular junction, acetylcholine receptors, preventive medicine, super-aging society, young people’s education, fermented papaya preparation, qol for seniors, skeletal muscle, mitochondrial metabolism, mitochondrial ca2+ signalling, aging, sarcopenia, mitochondria, mitochondrial permeability transition pore, reactive oxygen species, mitochondrial disease, neuromuscular activity, c. elegans, zebrafish, fbxl4, ageing, exercise, vasopressin, oxytocin, muscle trophism, cancer cachexia, non-coding rnas, single myofiber, atrophy, amyotrophic lateral sclerosis, endurance exercise, mouse models, prevention, immobilization, cochlea, electric stimulation, cochlear implant, padova anatomy school, endurance, health, epigenetics, electrostimulation, unilateral facial paralysis, electromyography, m. zygomaticus, transcranial direct current stimulation (tdcs), transcranial magnetic stimulation, schizophrenia, high density eeg, p50, p300, type 1 diabetes, muscle fiber conduction velocity, multi arrays electrodes, muscle and neural fatigue, mitochondrial respiratory capacity, bme, vo2max, mitobesity, comorbidities, early aging, label-free microscopy, mitochondrial fusion and fission, mitochondrial transplantation, energy metabolism, stem cells, oculopharyngeal muscular dystrophy, nucelar aggregates, pabpn1, endoplasmic reticulum stress, multiple acyl-coa dehydrogenase deficiency, fatty acid oxidation, etfdh, myomirs, riboflavin, ca2+ entry unit (ceu), sarcoplasmic reticulum (sr), store-operated ca2+ entry (soce), herg expression, c2c12 myotubes, gene upregulation, interferon gamma, upp, aging muscle, dynamic mri, compressed sensing, 3d strain imaging, %mvc, adipose content, connective tissue content, diffusion mri, diffusion modeling, biomarkers, muscle atrophy, neuromuscular maladaptation, bed rest, muscle ultrasound, muscle architecture, muscle tendon-unit, sarcomere, shear wave elastography, ultrasound, muscles, fasciae, reliability, variability, spinal cord injury, denervated degenerating muscle, home functional electrical stimulation, muscle co-activation, color computed tomography, functional recovery, skin, muscle, rehabilitation, physical activity, elderly, older adults, seniors, strength, power, training, excitation contraction (ec) coupling, muscle regeneration, cytokines, growth factors, muscle wasting, denervation, serological biomarkers, fes, atrophy and flattening, mouth fluids, circulating myokines, testosterone, hypogonadism, central core disease (ccd), functional electrical stimulation (fes), ryanodine receptor type-1 (ryr1), transcutaneous vagus nerve stimulation (tans), cymba conchae, auricular nerve, cortisol, platinum electrodes, arousal, stress, eda, scl, scr, cvxeda, computed tomography, numerical model, radiodensity, machine learning, cardiovascular conditions, excitation-contraction (ec) coupling, wartenberg pendulum test, spasticity, stroke, fascia, hyaluronan, vesicles, endocannabinoid, agonist, pain, peripheral effect, extra-cellular matrix, finite element model, mechanics, neutral lipid storage disease with myopathy, lipid droplets, adipose triglyceride lipase, micrornas, spinal muscular atrophy, survival motor neuron 1, imaging flow cytometry, anti-oxidant, fermented papaya, telomeres, muscle spindle, age, capsule, connective tissue, masters world records, rate of performance decay, gender differences, control of energy metabolism, mitochondrial database, mitochondrial respiration, reproducibility crisis, permeabilized muscle fibers, reference values, blood contamination, fibrinogen, non-invasive analyses, serum proteins, skeletal muscle atrophy, home-based full-body in-bed gym, older and oldest persons, strength and resistance training, postural exercise program, nanotechno- logical devices, multiple sclerosis, performance, nutrition, ctx, gymnastic, neurotrophins, il-4, il-10, il-17

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