Effects of aescin on cytochrome P450 enzymes in rats.

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Abstract

Aescin, the main active component found in extracts of horse chestnut (Aesculus hippocastanum) seed a traditional medicinal herb, is a mixture of triterpene saponins. It has been shown to be effective in inflammatory, chronic venous and edematous treatment conditions in vitro and in vivo, and is broadly used to treat chronic venous insufficiency. The purpose of this study was to find out whether aescin influences the effect on rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C9, CYP2E1 and CYP3A4) by using cocktail probe drugs in vivo; the influence on the levels of CYP mRNA was also studied.

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Author and article information

Journal

Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): 2014

Volume: 151

Issue: 1

Affiliations

[1 ] Wenzhou People's Hospital, Wenzhou 325000, China.

[2 ] The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

[3 ] The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

[4 ] The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: xuzhisheng1111@163.com.

[5 ] The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: xurenai1986@163.com.

Article

Publisher Item ID: S0378-8741(13)00810-6

DOI: 10.1016/j.jep.2013.11.016

PubMed ID: 24252494

SO-VID: af26f182-7ca8-4faa-8cfa-6293964badd8

History

Keywords: Aescin,mRNA,Herb-drug interaction,Cocktail,CYP

Data availability:

Keywords: Aescin, mRNA, Herb-drug interaction, Cocktail, CYP

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