KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy.

Trinka, Eugen; Marson, Anthony G; Van Paesschen, Wim; Kälviäinen, Reetta K.; Marovac, Jacqueline; Duncan, Benjamin-James A; Buyle, Sonja; Hallström, Yngve; Hon, Petr; Muscas, Gian Carlo; Newton, Mark; Meencke, Heinz-Joachim; Smith, Philip E M; Pohlmann-Eden, Bernd

doi:10.1136/jnnp-2011-300376

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KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy.

Author(s): Eugen Trinka ¹ , Anthony G Marson , Wim Van Paesschen , Reetta Kälviäinen , Jacqueline Marovac , Benjamin Duncan , Sonja Buyle , Yngve Hallström , Petr Hon , Gian Carlo Muscas , Mark Newton , Heinz-Joachim Meencke , Philip E Smith , Bernd Pohlmann-Eden

Publication date (Electronic): Oct 2013

Journal: Journal of neurology, neurosurgery, and psychiatry

Keywords: Levetiracetam, MRI, carbamazepine, clinical, epilepsy, monotherapy, neuroepidemiology, neurophysiol, surgery, valproic acid

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Abstract

To compare the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients with newly diagnosed epilepsy.

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Journal ID (iso-abbrev): J. Neurol. Neurosurg. Psychiatr.

Title: Journal of neurology, neurosurgery, and psychiatry

ISSN (Electronic): 1468-330X

ISSN (Print): 0022-3050

Publication date (Electronic): Oct 2013

Volume: 84

Issue: 10

Affiliations

[1 ] Department of Neurology, Paracelsus Medical University, Christian Doppler Klinik, Salzburg, Austria. e.trinka@salk.at

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Publisher Item ID: jnnp-2011-300376

DOI: 10.1136/jnnp-2011-300376

PubMed ID: 22933814

SO-VID: af2d7e7f-cfff-4733-8d77-c9f681acd679

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Keywords: Levetiracetam,MRI,carbamazepine,clinical,epilepsy,monotherapy,neuroepidemiology,neurophysiol,surgery,valproic acid

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Keywords: Levetiracetam, MRI, carbamazepine, clinical, epilepsy, monotherapy, neuroepidemiology, neurophysiol, surgery, valproic acid

KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy.

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