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      Plasma concentrations of tissue factor and its inhibitor in chronic thromboembolic pulmonary hypertension: a step closer to explanation of the disease aetiology?

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          Abstract

          The aetiology of chronic thromboembolic pulmonary hypertension (CTEPH) is not clearly understood. In some patients, the disease is preceded by acute pulmonary embolism (APE), and is characterised by intravascular thrombosis, vasoconstriction, inflammation and remodelling of pulmonary arteries. Ensuing pulmonary hypertension leads to potentially fatal chronic right ventricle failure. Both inborn and acquired risk factors were identified. Pathogenesis of haemostatic disorders is not completely explained, and extrinsic coagulation pathway disorders may play a role in CTEPH aetiology.

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          Author and article information

          Journal
          Kardiol Pol
          Kardiologia polska
          VM Media SP. zo.o VM Group SK
          1897-4279
          0022-9032
          2016
          : 74
          : 11
          Affiliations
          [1 ] Centra Medyczne Luxmed-Medycyna Rodzinna we Wrocławiu, Wojewówdzki Szpital Specjalistyczny we Wrocławiu - Ośrodek Badawczo-Rozwojowy. martacisowska1@wp.pl.
          Article
          VM/OJS/KP/10180
          10.5603/KP.a2016.0088
          27221958

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