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      Real-world outcomes of endovascular treatment in a non-selected population with peripheral artery disease – prospective study with 2-year follow-up

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          Abstract

          Summary. Background: The study aimed to evaluate the outcomes of percutaneous transluminal angioplasty (PTA) in lower-extremity peripheral artery disease (PAD) patients. Patients and methods: A multi-centre, observational study was performed with 32 German and Austrian centres contributing data to the PTA registry. Data of 1,781 patients with lower-leg and pelvic PAD who were suitable for endovascular PTA treatment were contributed from participating centres. Data from 1,533 patients are reported here (1,055 male and 478 female). This study did not have exclusion criteria. Quality of life (QOL) questionnaire (EQ-5D) scores, Rutherford classification, mortality, patency rate and details of major adverse cardiovascular events were collected at 6-, 12-, 18-, and 24-month follow ups. Results: PTA with/without stenting achieved 90.3 %, 86.5 %, 82.7 %, and 71.9 % technical success (recanalisation achieving ≥ 70 % patency, no evidence of embolisation, recoiling or dissection) in iliac, femoral, popliteal, and below-the-knee arteries, respectively. Procedural/postprocedural complications occurred in 142 (9.3 %, 1 death) and 74 (4.8 %) patients. QOL, mobility, self-care, activity, and pain/discomfort scores improved (p < 0.01), anxiety/depression was insignificantly improved. During follow-up, 409 (26.7 %) patients were hospitalised for PAD, 281 (18.3 %) required reintervention, and 145 (9.5 %) died or needed amputation (n = 49; 3.2 %). Multivariate analysis demonstrated poorer outcomes in patients with comorbidities. Conclusions: PTA with/without stenting is effective, safe, and widely applicable, with few complications. It improves QOL, but not anxiety/depression.

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          Most cited references 22

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          Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence

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                Author and article information

                Contributors
                Journal
                vas
                VASA
                European Journal of Vascular Medicine
                Hogrefe AG, Bern
                0301-1526
                1664-2872
                June 3, 2019
                August 22, 2019
                : 48
                : 5
                : 433-441
                Affiliations
                [ 1 ]Vascular Center Berlin/SGK Consulting Center, Berlin, Germany
                [ 2 ]Department of Angiology, St. Gertrauden Hospital, Berlin, Germany
                [ 3 ]Vascular Center/Clinic of Cardiology, Angiology, Marien-Hospital, Wesel, Germany
                [ 4 ]Vascular Center/Med. Clinic I, Henriettenstift, Hannover, Germany
                [ 5 ]Vascular Center/Angiology, Med. Clinic and Policlinic IV, Klinikum University München, Munich, Germany
                [ 6 ]Vascular Center Oberrhein, Internal Medicine I, Diakonissen-Hospital, Mannheim, Germany
                [ 7 ]Institute of Diagnostic and Interventional Radiology, RoMed Hospital Rosenheim, Rosenheim, Germany
                [ 8 ]Institute of Diagnostic and Interventional Radiology, Neuroradiology and Nuclear Medicine, Ruhr-University Bochum, Bochum, Germany
                [ 9 ]Institute of Medical Biometry and Epidemiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
                [ 10 ]MedDevConsult, Airport Center, Hamburg, Germany
                [ 11 ]Abbott Vascular Deutschland GmbH, Wetzlar, Germany
                Author notes
                [ a ]

                Steering committee

                Prof. Dr. Karl-Ludwig Schulte, Vascular Center Berlin, SGK Consulting Center, Paretzer Str. 12, 10713 Berlin, Germany, E-mail k-l.schulte@ 123456gefaesszentrum.berlin
                Article
                vas_48_5_433
                10.1024/0301-1526/a000798
                Product
                Self URI (journal page): https://econtent.hogrefe.com/loi/vas
                Funding
                Funding: This research was supported by an unrestricted grant from the German Society of Angiology/Vascular Medicine (DGA) and a group of German pharmaceutical and medical technology companies coordinated by the German Medical Technology Association (BVMed) . No contributor was involved in the conduct of this study.
                Categories
                Original communication

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