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      Renal Membrane Biosynthesis and Degradation. I. Studies on Rat Kidney Sialyl Transferases Utilizing Desialized Tamm-Horsfall Glycoprotein or Fetuin as Acceptors

      ,

      Nephron

      S. Karger AG

      Glycoprotein, Sialic acid, Glycosyl transferase

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          Abstract

          Glycoprotein: sialic acid transferase activity wasstudied in kidney tissue utilizing as exogenous acceptors desialized fetuin and desialized Tamm-Horsfall urinary glycoprotein. Activities were determined in cortex, medulla, and glomeruli. The effect of pH, divalent cations, and different protein acceptors was noted. The identity of the radioactive product formed was shown to be [<sup>14</sup>C]-N-acetylneuraminic acid labeled glycoprotein by hydrolysis and isolation of the radioactivity. This enzyme activity may prove useful in the study of renal pathology.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1973
          1973
          28 November 2008
          : 11
          : 1
          : 11-25
          Affiliations
          Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester N. Y.
          Article
          180215 Nephron 1973;11:11–25
          10.1159/000180215
          4757002
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 15
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Glycosyl transferase, Sialic acid, Glycoprotein

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