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      Effect of precise health management combined with physical rehabilitation on bone biomarkers in senile osteoporosis patients

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          Abstract

          This study delves into the impact of precise health management coupled with physical rehabilitation on bone biomarkers in elderly patients with osteoporosis. Two hundred and forty individuals diagnosed with senile osteoporosis were randomly assigned to either the observation group (precision health management group, n = 120) or the control group (routine health management group, n = 120). Patients in the control group received standard health care, while those in the observation group received personalized health care along with physical therapy. Pain levels (assessed by VAS score), understanding of osteoporosis, confidence in managing osteoporosis, bone density, and biochemical markers of bone metabolism were compared between the groups at 6, 12, 18, and 24 months before and after the intervention. Following the intervention, the observation group exhibited significantly reduced VAS values and PTH levels at 6, 12, 18, and 24 months compared to the control group ( P < 0.05). Additionally, scores on the Osteoporosis Knowledge Scale, Osteoporosis Self-Efficacy Scale, bone mineral density (BMD), ALP levels, and calcium levels were significantly higher in the observation group compared to the control group ( P < 0.05). The integration of precise health monitoring with tailored physical therapy shows substantial efficacy in reducing pain among elderly individuals suffering from osteoporosis. Moreover, it empowers them in managing their health effectively, while also contributing to increased BMD and improved bone biomarker levels. This holistic approach merits recommendation for clinical implementation and warrants further investigation through rigorous study.

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          Most cited references21

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          Effects of High‐Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One‐Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial ( FrOST )

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            Effects of a resistance and balance exercise programme on physical fitness, health-related quality of life and fear of falling in older women with osteoporosis and vertebral fracture: a randomized controlled trial.

            Exercise is recommended for people with osteoporosis, but the effect for people who have suffered vertebral fracture is uncertain. This study shows that a multicomponent exercise-program based on recommendations for people with osteoporosis improved muscle strength, balance, and fear of falling in older women with osteoporosis and vertebral fracture.
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              A Comparison of Bone‐Targeted Exercise Strategies to Reduce Fracture Risk in Middle‐Aged and Older Men with Osteopenia and Osteoporosis: LIFTMOR‐M Semi‐Randomized Controlled Trial

              The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR-M) trial examined efficacy and safety of two novel exercise programs in older men with low BMD. Men with low hip and/or LS BMD were randomized to high-intensity progressive resistance and impact training (HiRIT) or machine-based isometric axial compression (IAC) and compared to a nonrandomized matched control (CON). Outcomes included: hip and LS BMD; calcaneal ultrasound parameters; anthropometry; body composition; function (timed up-and-go [TUG], five-times sit-to-stand [FTSTS]); back extensor strength (BES); leg extensor strength (LES); compliance and adverse events. Ninety-three men (67.1 ± 7.5 years; 82.1 ± 11.6 kg; 175.2 ± 6.7 cm; FN T-score -1.6 ± 0.6) were randomized to HiRIT (n = 34) or IAC (n = 33), or allocated to CON (n = 26). HiRIT improved trochanteric BMD (2.8 ± 0.8%; -0.1 ± 0.9%, p = .024), LS BMD (4.1 ± 0.7%; 0.9 ± 0.8%, p = .003), BUA (2.2 ± 0.7%; -0.8 ± 0.9%, p = .009), stiffness index (1.6 ± 0.9%; -2.0 ± 1.1%, p = .011), lean mass (1.5 ± 0.8%; -2.4 ± 0.9%, p = .002), TUG, FTSTS, BES, and LES (p < .05) compared with CON. IAC improved lean mass (0.8 ± 0.8%; -2.4 ± 0.9%, p = .013) and FTSTS (-4.5 ± 1.6%; 7.5 ± 2.0%, p < .001) compared with CON. HiRIT improved LS BMD (4.1 ± 0.7%; 2.0 ± 0.7%, p = .039), stiffness index (1.6 ± 0.9%; -1.3 ± 0.9%, p = .025), and FTSTS (-10.7 ± 1.6%; -4.5 ± 1.7%, p = .010) compared with IAC. Exercise compliance was high (HiRIT 77.8 ± 16.6%; IAC 78.5 ± 14.8%, p = .872). There were five minor adverse events (HiRIT, 2; IAC, 3). HiRIT was well-tolerated and improved bone, function and fracture risk more than CON or IAC. © 2020 American Society for Bone and Mineral Research.

                Author and article information

                Contributors
                pyb-1977@163.com
                duzhixing@hebmu.edu.cn
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                20 January 2025
                20 January 2025
                2025
                : 15
                : 2458
                Affiliations
                Health Management Center, The First Hospital of Hebei Medical University, ( https://ror.org/04eymdx19) No.89 Donggang Road, Yuhua District, Shijiazhuang, 050000 Hebei Province China
                Article
                86188
                10.1038/s41598-025-86188-4
                11743755
                39828763
                af395ae0-b24d-4da0-b2da-d74248aff4e3
                © The Author(s) 2025

                Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

                History
                : 15 July 2024
                : 8 January 2025
                Funding
                Funded by: 2021 Hebei Province medical science research project
                Award ID: 20211302
                Award Recipient :
                Categories
                Article
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                © Springer Nature Limited 2025

                Uncategorized
                precise health management,physical rehabilitation,senile osteoporosis,bone biomarker,biomarkers,osteoporosis

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