+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Water Deprivation and Salt Loading on Atrial Natriuretic Peptide-Stimulated Guanylate Cyclase Activity in the Rat Subfornical Organ

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The effect of water deprivation and salt loading on rat atrial natriuretic peptide (99–126) (rANP)-stimulated guanylate cyclase activity was investigated in the rat subfomical organ. rANP stimulated the formation of cGMP in rat subfomical organ crude homogenates in a dose- and time-dependent manner. An elevated responsiveness to rANP-induced cGMP production was observed in the subfomical organ after 4 days of water deprivation; on the contrary, after salt loading the response to the cGMP-generating effects of ANP were less pronounced than those in the corresponding control tissue. Our results suggest that cGMP mediates at least some of the central actions of rANP through the activation of specific receptors in localized target sites, and they provide evidence suggesting that the guanylate cyclase-coupled ANP-binding sites are susceptible to the regulatory mechanism described in the rat subfomical organ.

          Related collections

          Author and article information

          S. Karger AG
          02 April 2008
          : 50
          : 3
          : 334-337
          aFaculty of Pharmacy and bBiomembranes Section, Institute of Experimental Medicine, Universidad Central de Venezuela, Caracas, Venezuela
          125242 Neuroendocrinology 1989;50:334–337
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Original Paper


          Comment on this article