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      Efeito da suplementação de colina protegida no perfil metabólico e intervalo entre parto e concepção de vacas leiteiras Translated title: [Prepartum supplementation of protected choline on metabolic profile and interval between calving and conception of dairy cows]

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          Abstract

          RESUMO Durante o periparto, as vacas leiteiras são submetidas a uma grande demanda de energia, ao mesmo tempo em que reduzem sua ingestão de matéria seca. O balanço energético negativo, resultante dessa equação, acarreta severos transtornos metabólicos, à produção e, principalmente, à reprodução. O objetivo do presente estudo foi avaliar o efeito da colina protegida sobre os parâmetros metabólicos, o intervalo entre parto e concepção e a produção de leite em vacas no período de transição. Cinquenta e quatro vacas leiteiras foram divididas em três grupos: controle, suplementação com colina por 10 dias pré-parto (T10) e suplementação com colina por 20 dias pré-parto (T20). Após o parto, foram mensurados os teores de frutosamina, colesterol, ácidos graxos não esterificados (AGNE), beta-hidroxibutirato (BHB), aspartato aminotransferase (AST), gamaglutamiltransferase (GGT) e total de oxidantes (TOS), nos dias 10, 20 e 30. Ainda foram avaliadas produção de leite e intervalo entre parto e concepção. Não houve efeito da suplementação com colina sobre os parâmetros sanguíneos e a produção. O intervalo entre parto e concepção foi menor no grupo T20. A colina suplementada por 20 dias durante o pré-parto melhorou a performance reprodutiva de vacas leiteiras

          Translated abstract

          ABSTRACT During the periparturient dairy cows undergo a large energy demand, at the same time reducing their intake of dry matter. The negative energy balance resulting from this equation leads to severe metabolic disorders in production, and mainly in reproduction. The aim of this study was to evaluate the effect of protected choline on metabolic parameters, reproductive performance, and milk production in cows during the transition period. Fifty-four dairy cows were divided into three groups: control, supplementation with choline for 10 days prepartum (T10) and supplementation with choline for 20 days prepartum (T20). After delivery we measured fructosamine levels, cholesterol, non-esterified fatty acids (NEFA), beta-hydroxybutyrate (BHB), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT), and total oxidant (TOS) on days 10, 20 and 30. We also evaluated milk production and interval between calving and conception. There was no effect of supplementation with choline on blood and production parameters. The interval between calving and conception was lower in the T20 group. Choline supplemented by 20 during the antepartum improved reproductive performance of dairy cows, although it did not change the metabolic profile.

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          Monitoring and testing dairy herds for metabolic disease.

          G Oetzel (2004)
          Clinical impressions of metabolic disease problems in dairy herds can be corroborated with herd-based metabolic testing. Ruminal pH should be evaluated in herds showing clinical signs associated with SARA (lame cows, thin cows, high herd removals or death loss across all stages of lactation, or milk fat depression). Testing a herd for the prevalence of SCK via blood BHB sampling in early lactation is useful in almost any dairy herd, and particularly if the herd is experiencing a high incidence of displaced abomasum or high removal rates of early lactation cows. If cows are experiencing SCK within the first 3 weeks of lactation, then consider NEFA testing of the prefresh cows to corroborate prefresh negative energy balance. Finally, monitoring cows on the day of calving for parturient hypocalcemia can provide early detection of diet-induced problems in calcium homeostasis. If hypocalcemia problems are present despite supplementing anionic salts before calving, then it may be helpful to evaluate mean urinary pH of a group of the prefresh cows. Quantitative testing strategies based on statistical analyses can be used to establish minimum sample sizes and interpretation guidelines for all of these tests.
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            Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows.

            Subclinical ketosis (SCK) is defined as concentrations of β-hydroxybutyrate (BHBA) ≥ 1.2 to 1.4 mmol/L and it is considered a gateway condition for other metabolic and infectious disorders such as metritis, mastitis, clinical ketosis, and displaced abomasum. Reported prevalence rates range from 6.9 to 43% in the first 2 mo of lactation. However, there is a dearth of information on prevalence rates considering the diversity of European dairy farms. The objectives of this study were to (1) determine prevalence of SCK, (2) identify thresholds of BHBA, and (3) study their relationships with postpartum metritis, clinical ketosis, displaced abomasum, lameness, and mastitis in European dairy farms. From May to October 2011, a convenience sample of 528 dairy herds from Croatia, Germany, Hungary, Italy, Poland, Portugal, Serbia, Slovenia, Spain, and Turkey was studied. β-Hydroxybutyrate levels were measured in 5,884 cows with a handheld meter within 2 to 15 d in milk (DIM). On average, 11 cows were enrolled per farm and relevant information (e.g., DIM, postpartum diseases, herd size) was recorded. Using receiver operator characteristic curve analyses, blood BHBA thresholds were determined for the occurrence of metritis, mastitis, clinical ketosis, displaced abomasum, and lameness. Multivariate binary logistic regression models were built for each disease, considering cow as the experimental unit and herd as a random effect. Overall prevalence of SCK (i.e., blood BHBA ≥ 1.2 mmol/L) within 10 countries was 21.8%, ranging from 11.2 to 36.6%. Cows with SCK had 1.5, 9.5, and 5.0 times greater odds of developing metritis, clinical ketosis, and displaced abomasum, respectively. Multivariate binary logistic regression models demonstrated that cows with blood BHBA levels of ≥ 1.4, ≥ 1.1 and ≥ 1.7 mmol/L during 2 to 15 DIM had 1.7, 10.5, and 6.9 times greater odds of developing metritis, clinical ketosis, and displaced abomasum, respectively, compared with cows with lower BHBA blood levels. Interestingly, a postpartum blood BHBA threshold ≥ 1.1 mmol/L increased the odds for lameness in dairy cows 1.8 (95% confidence interval: 1.3 to 2.5) times. Overall, prevalence of SCK was high between 2 to 15 DIM and SCK increased the odds of metritis, clinical ketosis, lameness, and displaced abomasum in European dairy herds.
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              Dry matter intake and energy balance in the transition period.

              It is easy, based on theoretic considerations, to make the argument that maximizing DMI is important to minimize postpartum complications and losses in milk production that may be associated with them. However, research over the past several years provides ample evidence that successful "passage" through the periparturient period is more complicated than simply maximizing feed intake. Anecdotal evidence from veterinarians and nutrition consultants also confirm that feeding low-NDF diets to achieve high prepartum feed intakes during the prefresh transition period does not necessarily solve fresh-cow problems. Perhaps more important than maximizing feed intake is to minimize the likelihood of cows experiencing large drops in feed intake immediately before parturition. Retrospective analysis of existing data sets indicates that this hypothesis has merit; research must be conducted to vigorously test it. Until then, it seems reasonable to try to achieve high DMI, if it can be sustained through parturition. If it cannot, perhaps a more conservative approach is to limit voluntary intake by increasing dietary fiber, because data suggests that cows fed in such a manner experience less dramatic decreases in feed intake as parturition approaches. We examined the importance of parity, body condition score, and various diet components that may influence DMI during the final 3 weeks before parturition, but they only explained 18% of the variation in intake among cows. Clearly, there are many other factors that affect intake that need to be identified. Aspects of farm management that may influence animal stress need to be investigated, particularly during the prefresh transition period when cows are inherently prone to reductions in feed intake.
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                Author and article information

                Journal
                abmvz
                Arquivo Brasileiro de Medicina Veterinária e Zootecnia
                Arq. Bras. Med. Vet. Zootec.
                Universidade Federal de Minas Gerais, Escola de Veterinária (Belo Horizonte, MG, Brazil )
                0102-0935
                1678-4162
                April 2020
                : 72
                : 2
                : 553-559
                Affiliations
                [1] Santa Cruz do Sul Rio Grande do Sul orgnameUniversidade de Santa Cruz do Sul Brazil
                [2] Xanxerê Santa Catarina orgnameUniversidade do Oeste de Santa Catarina Brazil
                [3] Santa Maria Rio Grande do Sul orgnameUniversidade Federal de Santa Maria Brazil
                Article
                S0102-09352020000200553 S0102-0935(20)07200200553
                10.1590/1678-4162-10078
                af5b2d07-149c-4372-90fe-8797e0b973c4

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 08 June 2017
                : 27 March 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 29, Pages: 7
                Product

                SciELO Brazil

                Self URI: Texto completo somente em PDF (PT)
                Categories
                Zootecnia e Tecnologia e Inspeção de Produtos de Origem Animal

                prepartum,cows,pré-parto,reproduction,vitamin,metabolic parameters,parâmetros metabólicos,reprodução,vacas,vitamina

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